Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease

Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease

Abstract Antioxidant enzyme therapy shows promise for treating Alzheimer’s disease (AD), but significant challenges remain in achieving effective blood–brain barrier (BBB) penetration and sustained therapeutic effects. We developed a novel neutrophil membrane (NM)-coated cerium-doped Prussian blue b...

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Bibliographic Details
Main Authors: Jing Ma, Yu Tian, Chengzhong Du, Yang Zhu, Wen Huang, Chenyu Ding, Penghui Wei, Xuehan Yi, Zhangya Lin, Wenhua Fang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Nanozyme
Alzheimer’s disease
Pyroptosis
Reactive oxygen species
Neuroinflammation
Online Access:https://doi.org/10.1186/s12951-025-03263-8
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