Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation
Saccade adaptation is a cerebellar-mediated type of motor learning in which the oculomotor system is exposed to repetitive errors. Different types of saccade adaptations are thought to involve distinct underlying cerebellar mechanisms. Transcranial direct current stimulation (tDCS) induces changes i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/968970 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850223712031211520 |
|---|---|
| author | Eric Avila Jos N. van der Geest Sandra Kengne Kamga M. Claire Verhage Opher Donchin Maarten A. Frens |
| author_facet | Eric Avila Jos N. van der Geest Sandra Kengne Kamga M. Claire Verhage Opher Donchin Maarten A. Frens |
| author_sort | Eric Avila |
| collection | DOAJ |
| description | Saccade adaptation is a cerebellar-mediated type of motor learning in which the oculomotor system is exposed to repetitive errors. Different types of saccade adaptations are thought to involve distinct underlying cerebellar mechanisms. Transcranial direct current stimulation (tDCS) induces changes in neuronal excitability in a polarity-specific manner and offers a modulatory, noninvasive, functional insight into the learning aspects of different brain regions. We aimed to modulate the cerebellar influence on saccade gains during adaptation using tDCS. Subjects performed an inward (n=10) or outward (n=10) saccade adaptation experiment (25% intrasaccadic target step) while receiving 1.5 mA of anodal cerebellar tDCS delivered by a small contact electrode. Compared to sham stimulation, tDCS increased learning of saccadic inward adaptation but did not affect learning of outward adaptation. This may imply that plasticity mechanisms in the cerebellum are different between inward and outward adaptation. TDCS could have influenced specific cerebellar areas that contribute to inward but not outward adaptation. We conclude that tDCS can be used as a neuromodulatory technique to alter cerebellar oculomotor output, arguably by engaging wider cerebellar areas and increasing the available resources for learning. |
| format | Article |
| id | doaj-art-449ec83a078142d4a3036b7d2dd86cb7 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-449ec83a078142d4a3036b7d2dd86cb72025-08-20T02:05:51ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/968970968970Cerebellar Transcranial Direct Current Stimulation Effects on Saccade AdaptationEric Avila0Jos N. van der Geest1Sandra Kengne Kamga2M. Claire Verhage3Opher Donchin4Maarten A. Frens5Department of Neuroscience, Erasmus MC, 3000 CA Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, 3000 CA Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, 3000 CA Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, 3000 CA Rotterdam, NetherlandsDepartment of Biomedical Engineering, Ben Gurion University of the Negev, 84105 Beer-Sheva, IsraelDepartment of Neuroscience, Erasmus MC, 3000 CA Rotterdam, NetherlandsSaccade adaptation is a cerebellar-mediated type of motor learning in which the oculomotor system is exposed to repetitive errors. Different types of saccade adaptations are thought to involve distinct underlying cerebellar mechanisms. Transcranial direct current stimulation (tDCS) induces changes in neuronal excitability in a polarity-specific manner and offers a modulatory, noninvasive, functional insight into the learning aspects of different brain regions. We aimed to modulate the cerebellar influence on saccade gains during adaptation using tDCS. Subjects performed an inward (n=10) or outward (n=10) saccade adaptation experiment (25% intrasaccadic target step) while receiving 1.5 mA of anodal cerebellar tDCS delivered by a small contact electrode. Compared to sham stimulation, tDCS increased learning of saccadic inward adaptation but did not affect learning of outward adaptation. This may imply that plasticity mechanisms in the cerebellum are different between inward and outward adaptation. TDCS could have influenced specific cerebellar areas that contribute to inward but not outward adaptation. We conclude that tDCS can be used as a neuromodulatory technique to alter cerebellar oculomotor output, arguably by engaging wider cerebellar areas and increasing the available resources for learning.http://dx.doi.org/10.1155/2015/968970 |
| spellingShingle | Eric Avila Jos N. van der Geest Sandra Kengne Kamga M. Claire Verhage Opher Donchin Maarten A. Frens Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation Neural Plasticity |
| title | Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation |
| title_full | Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation |
| title_fullStr | Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation |
| title_full_unstemmed | Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation |
| title_short | Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation |
| title_sort | cerebellar transcranial direct current stimulation effects on saccade adaptation |
| url | http://dx.doi.org/10.1155/2015/968970 |
| work_keys_str_mv | AT ericavila cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation AT josnvandergeest cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation AT sandrakengnekamga cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation AT mclaireverhage cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation AT opherdonchin cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation AT maartenafrens cerebellartranscranialdirectcurrentstimulationeffectsonsaccadeadaptation |