Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery
Background: The laryngoscopy and tracheal intubation is a noxious stimuli resulting in transient but marked sympathetic response. This response is exaggerated in patients with hypertension. This study evaluated the role of oral pregabalin premedication in attenuation of haemodynamic response during...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2024-09-01
|
| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/949 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850137141750792192 |
|---|---|
| author | Surabhi Sandill Mhonchumi Khuvung Rajpal Singh Udismita Baruah |
| author_facet | Surabhi Sandill Mhonchumi Khuvung Rajpal Singh Udismita Baruah |
| author_sort | Surabhi Sandill |
| collection | DOAJ |
| description |
Background: The laryngoscopy and tracheal intubation is a noxious stimuli resulting in transient but marked sympathetic response. This response is exaggerated in patients with hypertension. This study evaluated the role of oral pregabalin premedication in attenuation of haemodynamic response during tracheal intubation in adult patients with controlled hypertension posted for elective surgery.
Methods: A prospective double blinded randomized study was carried out in a total of 60 adult patients (aged 18-65 years, either gender) with controlled hypertension after being randomized into two groups with 30 patients in each. Prior to induction, Group PL received Placebo (multivitamin) and Group PB received pregabalin 75mg tablet 1 hour. The anaesthesia technique was standardized as per department protocols. Both groups were evaluated for pre-operative sedation, haemodynamic changes after premedication, before and after induction, after the laryngoscopy and tracheal intubation and post-operative side effects.
Results: There was attenuation of haemodynamic responses without significant side effects with pregabalin. Statistically significant increase in post intubation systolic, diastolic and mean blood pressure was seen in group PL as compared to group PB. In both groups, a reduction in heart rate was observed and was statistically significant 1 minute after intubation in group PB. Pre-operative sedation levels were higher in PB group in comparison to PL group. No post-operative side effects observed in both the groups.
Conclusion: In controlled hypertensive patients, oral pregabalin 75 mg attenuated the haemodynamic responses to laryngoscopy and tracheal intubation. It produced effective pre-operative sedation without any post-operative side effects.
|
| format | Article |
| id | doaj-art-449d1b0cc8d2411aa644094280e46d7a |
| institution | OA Journals |
| issn | 2423-5849 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj-art-449d1b0cc8d2411aa644094280e46d7a2025-08-20T02:30:56ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492024-09-0110Supp. 2Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective SurgerySurabhi Sandill0Mhonchumi Khuvung1Rajpal Singh2Udismita Baruah3Department of Onco-Anaesthesia and Palliative Medicine, Dr. B.R.A.I.R.C.H., AIIMS, New Delhi, India.Department of Anaesthesia, CIHSR, Dimapur, Nagaland, India.Department of Anaesthesia and Critical Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.Department of Anaesthesia and Critical Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Background: The laryngoscopy and tracheal intubation is a noxious stimuli resulting in transient but marked sympathetic response. This response is exaggerated in patients with hypertension. This study evaluated the role of oral pregabalin premedication in attenuation of haemodynamic response during tracheal intubation in adult patients with controlled hypertension posted for elective surgery. Methods: A prospective double blinded randomized study was carried out in a total of 60 adult patients (aged 18-65 years, either gender) with controlled hypertension after being randomized into two groups with 30 patients in each. Prior to induction, Group PL received Placebo (multivitamin) and Group PB received pregabalin 75mg tablet 1 hour. The anaesthesia technique was standardized as per department protocols. Both groups were evaluated for pre-operative sedation, haemodynamic changes after premedication, before and after induction, after the laryngoscopy and tracheal intubation and post-operative side effects. Results: There was attenuation of haemodynamic responses without significant side effects with pregabalin. Statistically significant increase in post intubation systolic, diastolic and mean blood pressure was seen in group PL as compared to group PB. In both groups, a reduction in heart rate was observed and was statistically significant 1 minute after intubation in group PB. Pre-operative sedation levels were higher in PB group in comparison to PL group. No post-operative side effects observed in both the groups. Conclusion: In controlled hypertensive patients, oral pregabalin 75 mg attenuated the haemodynamic responses to laryngoscopy and tracheal intubation. It produced effective pre-operative sedation without any post-operative side effects. https://aacc.tums.ac.ir/index.php/aacc/article/view/949Controlled hypertensionTracheal intubationHaemodynamic responsePregabalin |
| spellingShingle | Surabhi Sandill Mhonchumi Khuvung Rajpal Singh Udismita Baruah Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery Archives of Anesthesia and Critical Care Controlled hypertension Tracheal intubation Haemodynamic response Pregabalin |
| title | Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery |
| title_full | Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery |
| title_fullStr | Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery |
| title_full_unstemmed | Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery |
| title_short | Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery |
| title_sort | evaluation of oral pregabalin premedication for attenuation of haemodynamic response during tracheal intubation in adult patients with controlled hypertension for elective surgery |
| topic | Controlled hypertension Tracheal intubation Haemodynamic response Pregabalin |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/949 |
| work_keys_str_mv | AT surabhisandill evaluationoforalpregabalinpremedicationforattenuationofhaemodynamicresponseduringtrachealintubationinadultpatientswithcontrolledhypertensionforelectivesurgery AT mhonchumikhuvung evaluationoforalpregabalinpremedicationforattenuationofhaemodynamicresponseduringtrachealintubationinadultpatientswithcontrolledhypertensionforelectivesurgery AT rajpalsingh evaluationoforalpregabalinpremedicationforattenuationofhaemodynamicresponseduringtrachealintubationinadultpatientswithcontrolledhypertensionforelectivesurgery AT udismitabaruah evaluationoforalpregabalinpremedicationforattenuationofhaemodynamicresponseduringtrachealintubationinadultpatientswithcontrolledhypertensionforelectivesurgery |