SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis

SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis

Abstract Background Endometrial cancer (EC) is a significant and serious gynecological cancer, constituting a considerable risk to women's health. The desumoylation of SUMO specific peptidase 5 (SENP5) is intricately linked with various cancers. Nonetheless, the function of SENP5 in EC and its...

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Bibliographic Details
Main Authors: Ziyuan Wang, Yongmei Zhang, Yongfang Zhang, Qiuhong Deng, Yandong Xi, Wanxia He, Xiaolong Ma
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Endometrial cancer
Ferroptosis
DeSUMOylation
SENP5
β-Catenin
GPX4
Online Access:https://doi.org/10.1186/s40001-025-02662-9
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