Statins and their impact on epigenetic regulation: insights into disease
Statins have been primarily used for the management of low-density lipoprotein cholesterol and cardiovascular diseases However, in recent years, research has identified potential applications beyond cholesterol regulation. Statins exhibit pleiotropic effects, due to their ability to modulate gene ex...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1621163/full |
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| author | Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Santiago Cadena-Ullauri Viviana A. Ruiz Pozo Elius Paz-Cruz Ana Karina Zambrano |
| author_facet | Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Santiago Cadena-Ullauri Viviana A. Ruiz Pozo Elius Paz-Cruz Ana Karina Zambrano |
| author_sort | Rafael Tamayo-Trujillo |
| collection | DOAJ |
| description | Statins have been primarily used for the management of low-density lipoprotein cholesterol and cardiovascular diseases However, in recent years, research has identified potential applications beyond cholesterol regulation. Statins exhibit pleiotropic effects, due to their ability to modulate gene expression via epigenetic mechanisms, including DNA methylation, histone acetylation, and microRNA regulation. Clinical studies have correlated these epigenetic changes with various pathological conditions, such as inflammation, atherosclerosis, cancer, diabetes, and autoimmune disorders. Despite encouraging findings, further research is required to fully understand the molecular pathways associated with the epigenetic actions of statins and disease pathogenesis. This review describes the potential role of statins as epigenetic modulators and their relevance in human disease management. |
| format | Article |
| id | doaj-art-449bf2fd1f8f43a4805c3ef0f5290fe5 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-449bf2fd1f8f43a4805c3ef0f5290fe52025-08-20T03:51:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16211631621163Statins and their impact on epigenetic regulation: insights into diseaseRafael Tamayo-TrujilloPatricia Guevara-RamírezSantiago Cadena-UllauriViviana A. Ruiz PozoElius Paz-CruzAna Karina ZambranoStatins have been primarily used for the management of low-density lipoprotein cholesterol and cardiovascular diseases However, in recent years, research has identified potential applications beyond cholesterol regulation. Statins exhibit pleiotropic effects, due to their ability to modulate gene expression via epigenetic mechanisms, including DNA methylation, histone acetylation, and microRNA regulation. Clinical studies have correlated these epigenetic changes with various pathological conditions, such as inflammation, atherosclerosis, cancer, diabetes, and autoimmune disorders. Despite encouraging findings, further research is required to fully understand the molecular pathways associated with the epigenetic actions of statins and disease pathogenesis. This review describes the potential role of statins as epigenetic modulators and their relevance in human disease management.https://www.frontiersin.org/articles/10.3389/fphar.2025.1621163/fullpharmacologypharmacoepigeneticsepigeneticsstatinsmolecular biologyhealthcare and well-being |
| spellingShingle | Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Santiago Cadena-Ullauri Viviana A. Ruiz Pozo Elius Paz-Cruz Ana Karina Zambrano Statins and their impact on epigenetic regulation: insights into disease Frontiers in Pharmacology pharmacology pharmacoepigenetics epigenetics statins molecular biology healthcare and well-being |
| title | Statins and their impact on epigenetic regulation: insights into disease |
| title_full | Statins and their impact on epigenetic regulation: insights into disease |
| title_fullStr | Statins and their impact on epigenetic regulation: insights into disease |
| title_full_unstemmed | Statins and their impact on epigenetic regulation: insights into disease |
| title_short | Statins and their impact on epigenetic regulation: insights into disease |
| title_sort | statins and their impact on epigenetic regulation insights into disease |
| topic | pharmacology pharmacoepigenetics epigenetics statins molecular biology healthcare and well-being |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1621163/full |
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