Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils

Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils

Abstract Accumulating evidence highlights that dysfunction of astrocyte biology might contribute to Parkinson’s disease (PD) onset and progression. Leucine-rich repeat kinase 2 (LRRK2), a gene linked to genetic and familial PD, has been reported to affect astrocytic-related functions, including the...

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Bibliographic Details
Main Authors: Alice Filippini, Giulia Carini, Alessandro Barbon, Massimo Gennarelli, Isabella Russo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
LRRK2
Clusterin
Parkinson’s disease
Astrocytes
miRNA
Online Access:https://doi.org/10.1186/s40478-025-02015-x
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