Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque
Atherosclerosis is a chronic, progressive, multifocal arterial wall disease caused by local and systemic inflammation responsible for major cardiovascular complications such as myocardial infarction and stroke. With the recent understanding that vulnerable plaque erosion and rupture, with subsequent...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/410967 |
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| author | Sunny Goel Avraham Miller Chirag Agarwal Elina Zakin Michael Acholonu Umesh Gidwani Abhishek Sharma Guy Kulbak Jacob Shani On Chen |
| author_facet | Sunny Goel Avraham Miller Chirag Agarwal Elina Zakin Michael Acholonu Umesh Gidwani Abhishek Sharma Guy Kulbak Jacob Shani On Chen |
| author_sort | Sunny Goel |
| collection | DOAJ |
| description | Atherosclerosis is a chronic, progressive, multifocal arterial wall disease caused by local and systemic inflammation responsible for major cardiovascular complications such as myocardial infarction and stroke. With the recent understanding that vulnerable plaque erosion and rupture, with subsequent thrombosis, rather than luminal stenosis, is the underlying cause of acute ischemic events, there has been a shift of focus to understand the mechanisms that make an atherosclerotic plaque unstable or vulnerable to rupture. The presence of inflammation in the atherosclerotic plaque has been considered as one of the initial events which convert a stable plaque into an unstable and vulnerable plaque. This paper systemically reviews the noninvasive and invasive imaging modalities that are currently available to detect this inflammatory process, at least in the intermediate stages, and discusses the ongoing studies that will help us to better understand and identify it at the molecular level. |
| format | Article |
| id | doaj-art-4499e70a2d43478ab3dc1a96405ca941 |
| institution | OA Journals |
| issn | 2090-1941 2090-195X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj-art-4499e70a2d43478ab3dc1a96405ca9412025-08-20T02:37:48ZengWileyRadiology Research and Practice2090-19412090-195X2015-01-01201510.1155/2015/410967410967Imaging Modalities to Identity Inflammation in an Atherosclerotic PlaqueSunny Goel0Avraham Miller1Chirag Agarwal2Elina Zakin3Michael Acholonu4Umesh Gidwani5Abhishek Sharma6Guy Kulbak7Jacob Shani8On Chen9Department of Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USADepartment of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Cardiology, Maimonides Medical Center, Brooklyn, NY 11219, USAAtherosclerosis is a chronic, progressive, multifocal arterial wall disease caused by local and systemic inflammation responsible for major cardiovascular complications such as myocardial infarction and stroke. With the recent understanding that vulnerable plaque erosion and rupture, with subsequent thrombosis, rather than luminal stenosis, is the underlying cause of acute ischemic events, there has been a shift of focus to understand the mechanisms that make an atherosclerotic plaque unstable or vulnerable to rupture. The presence of inflammation in the atherosclerotic plaque has been considered as one of the initial events which convert a stable plaque into an unstable and vulnerable plaque. This paper systemically reviews the noninvasive and invasive imaging modalities that are currently available to detect this inflammatory process, at least in the intermediate stages, and discusses the ongoing studies that will help us to better understand and identify it at the molecular level.http://dx.doi.org/10.1155/2015/410967 |
| spellingShingle | Sunny Goel Avraham Miller Chirag Agarwal Elina Zakin Michael Acholonu Umesh Gidwani Abhishek Sharma Guy Kulbak Jacob Shani On Chen Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque Radiology Research and Practice |
| title | Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque |
| title_full | Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque |
| title_fullStr | Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque |
| title_full_unstemmed | Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque |
| title_short | Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque |
| title_sort | imaging modalities to identity inflammation in an atherosclerotic plaque |
| url | http://dx.doi.org/10.1155/2015/410967 |
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