Excess single-stranded DNA inhibits meiotic double-strand break repair.

Excess single-stranded DNA inhibits meiotic double-strand break repair.

During meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation is vital for the segregation of homologous chromosomes during the first meiotic division and requir...

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Bibliographic Details
Main Authors: Rebecca Johnson, Valérie Borde, Matthew J Neale, Anna Bishop-Bailey, Matthew North, Sheila Harris, Alain Nicolas, Alastair S H Goldman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-11-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030223&type=printable
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