The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia
Introduction. Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials. The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D suppl...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2017/8249264 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545640797700096 |
|---|---|
| author | Sanam Behjat Sasan Farnaz Zandvakili Nasrin Soufizadeh Elaheh Baybordi |
| author_facet | Sanam Behjat Sasan Farnaz Zandvakili Nasrin Soufizadeh Elaheh Baybordi |
| author_sort | Sanam Behjat Sasan |
| collection | DOAJ |
| description | Introduction. Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials. The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results. The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71). Conclusion. The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration. This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1. |
| format | Article |
| id | doaj-art-4499d09090d041108f26715f9a383899 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-4499d09090d041108f26715f9a3838992025-02-03T07:25:13ZengWileyObstetrics and Gynecology International1687-95891687-95972017-01-01201710.1155/2017/82492648249264The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of PreeclampsiaSanam Behjat Sasan0Farnaz Zandvakili1Nasrin Soufizadeh2Elaheh Baybordi3Department of Gynecology, School of Medicine, Kurdistan University of Medical Science, Sanandaj, IranDepartment of Gynecology, School of Medicine, Kurdistan University of Medical Science, Sanandaj, IranDepartment of Gynecology, School of Medicine, Kurdistan University of Medical Science, Sanandaj, IranEast Azerbaijan ACECR Medical Center, Tabriz, IranIntroduction. Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials. The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results. The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71). Conclusion. The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration. This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1.http://dx.doi.org/10.1155/2017/8249264 |
| spellingShingle | Sanam Behjat Sasan Farnaz Zandvakili Nasrin Soufizadeh Elaheh Baybordi The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia Obstetrics and Gynecology International |
| title | The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia |
| title_full | The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia |
| title_fullStr | The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia |
| title_full_unstemmed | The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia |
| title_short | The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia |
| title_sort | effects of vitamin d supplement on prevention of recurrence of preeclampsia in pregnant women with a history of preeclampsia |
| url | http://dx.doi.org/10.1155/2017/8249264 |
| work_keys_str_mv | AT sanambehjatsasan theeffectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT farnazzandvakili theeffectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT nasrinsoufizadeh theeffectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT elahehbaybordi theeffectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT sanambehjatsasan effectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT farnazzandvakili effectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT nasrinsoufizadeh effectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia AT elahehbaybordi effectsofvitamindsupplementonpreventionofrecurrenceofpreeclampsiainpregnantwomenwithahistoryofpreeclampsia |