Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study

Acinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but h...

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Main Authors: Kiyoshi Shingu, Tokiko Ito, Gengo Kaneko, Nobuo Itoh
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2013/372947
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author Kiyoshi Shingu
Tokiko Ito
Gengo Kaneko
Nobuo Itoh
author_facet Kiyoshi Shingu
Tokiko Ito
Gengo Kaneko
Nobuo Itoh
author_sort Kiyoshi Shingu
collection DOAJ
description Acinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but had a firm consistency. It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. Many of the tumor cells had abundant clear vacuolated cytoplasm containing zymogen-typed granules which resemble acinar cells of the salivary glands. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. She received postoperative chemoradiation therapy and has been well for 3 years since surgery. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast.
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spelling doaj-art-4494139781e342ea8d71773a2c822e502025-02-03T06:42:15ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/372947372947Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical StudyKiyoshi Shingu0Tokiko Ito1Gengo Kaneko2Nobuo Itoh3Departments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanDepartments of Surgery and Pathology, Iida Municipal Hospital, 438 Yawatacho, Iida, Nagano 395-8502, JapanAcinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but had a firm consistency. It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. Many of the tumor cells had abundant clear vacuolated cytoplasm containing zymogen-typed granules which resemble acinar cells of the salivary glands. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. She received postoperative chemoradiation therapy and has been well for 3 years since surgery. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast.http://dx.doi.org/10.1155/2013/372947
spellingShingle Kiyoshi Shingu
Tokiko Ito
Gengo Kaneko
Nobuo Itoh
Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
Case Reports in Oncological Medicine
title Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
title_full Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
title_fullStr Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
title_full_unstemmed Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
title_short Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study
title_sort primary acinic cell carcinoma of the breast a clinicopathological and immunohistochemical study
url http://dx.doi.org/10.1155/2013/372947
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AT tokikoito primaryaciniccellcarcinomaofthebreastaclinicopathologicalandimmunohistochemicalstudy
AT gengokaneko primaryaciniccellcarcinomaofthebreastaclinicopathologicalandimmunohistochemicalstudy
AT nobuoitoh primaryaciniccellcarcinomaofthebreastaclinicopathologicalandimmunohistochemicalstudy