Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review
Background Pre-eclampsia (PE) affects 2–8% of pregnant women and is a major cause of maternal and perinatal complications. Early risk identification is critical to reducing maternal and neonatal mortality and morbidity.Objective This systematic review evaluates the role of ophthalmic Doppler arterie...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Hypertension in Pregnancy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641955.2025.2506451 |
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| author | Meta Amelia Winnee Hana Siahaan Nicholas Wijaya Arif Maulana Harahap Mouza Abiyyu Rivany Sarma Nursani Lumbanraja |
| author_facet | Meta Amelia Winnee Hana Siahaan Nicholas Wijaya Arif Maulana Harahap Mouza Abiyyu Rivany Sarma Nursani Lumbanraja |
| author_sort | Meta Amelia |
| collection | DOAJ |
| description | Background Pre-eclampsia (PE) affects 2–8% of pregnant women and is a major cause of maternal and perinatal complications. Early risk identification is critical to reducing maternal and neonatal mortality and morbidity.Objective This systematic review evaluates the role of ophthalmic Doppler arteries parameters, combined with maternal risk factors, physical examination results, and laboratory results for PE screening.Methods Relevant articles were identified from PubMed, Wiley Online Library, and ScienceDirect using predefined inclusion and exclusion criteria. Articles were screened in two stages – primary extraction by title and abstract, followed by full-text evaluation. The final analysis included observational studies and randomized trials assessing PE prediction using ophthalmic Doppler artery indices.Results Of the 103 records screened, 24 articles were retrieved, and 7 met the eligibility criteria. All studies examined ophthalmic artery Doppler parameters – especially the peak systolic velocity (PSV) ratio – for PE screening across different gestational ages. The PSV ratio showed moderate-to-high predictive value when combined with established clinical biomarkers.Conclusion The ophthalmic Doppler artery is regarded as a viable alternative or combination for early detection of PE that is simple to implement and effective, particularly in healthcare facilities in developing countries. However, further large-scale, externally validated studies are needed to establish its clinical utility across different gestational stages. |
| format | Article |
| id | doaj-art-448e36ce370a48688a54fac2e1811cb7 |
| institution | OA Journals |
| issn | 1064-1955 1525-6065 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj-art-448e36ce370a48688a54fac2e1811cb72025-08-20T02:03:16ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652025-12-0144110.1080/10641955.2025.2506451Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic reviewMeta Amelia0Winnee Hana Siahaan1Nicholas Wijaya2Arif Maulana Harahap3Mouza Abiyyu Rivany4Sarma Nursani Lumbanraja5Department of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, IndonesiaBackground Pre-eclampsia (PE) affects 2–8% of pregnant women and is a major cause of maternal and perinatal complications. Early risk identification is critical to reducing maternal and neonatal mortality and morbidity.Objective This systematic review evaluates the role of ophthalmic Doppler arteries parameters, combined with maternal risk factors, physical examination results, and laboratory results for PE screening.Methods Relevant articles were identified from PubMed, Wiley Online Library, and ScienceDirect using predefined inclusion and exclusion criteria. Articles were screened in two stages – primary extraction by title and abstract, followed by full-text evaluation. The final analysis included observational studies and randomized trials assessing PE prediction using ophthalmic Doppler artery indices.Results Of the 103 records screened, 24 articles were retrieved, and 7 met the eligibility criteria. All studies examined ophthalmic artery Doppler parameters – especially the peak systolic velocity (PSV) ratio – for PE screening across different gestational ages. The PSV ratio showed moderate-to-high predictive value when combined with established clinical biomarkers.Conclusion The ophthalmic Doppler artery is regarded as a viable alternative or combination for early detection of PE that is simple to implement and effective, particularly in healthcare facilities in developing countries. However, further large-scale, externally validated studies are needed to establish its clinical utility across different gestational stages.https://www.tandfonline.com/doi/10.1080/10641955.2025.2506451opthalmic Doppler arterypre-eclampsiascreeningpregnancy |
| spellingShingle | Meta Amelia Winnee Hana Siahaan Nicholas Wijaya Arif Maulana Harahap Mouza Abiyyu Rivany Sarma Nursani Lumbanraja Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review Hypertension in Pregnancy opthalmic Doppler artery pre-eclampsia screening pregnancy |
| title | Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review |
| title_full | Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review |
| title_fullStr | Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review |
| title_full_unstemmed | Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review |
| title_short | Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review |
| title_sort | pre eclampsia screening with maternal risk factors and ophthalmic doppler artery a systematic review |
| topic | opthalmic Doppler artery pre-eclampsia screening pregnancy |
| url | https://www.tandfonline.com/doi/10.1080/10641955.2025.2506451 |
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