The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study
Purpose: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB). Materials and Methods: Data from 1,230 consecutive men presenting for primary couple’s infertility were analyzed. Healthsignificant comorbidities were scored with Charlson comorbidity...
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Korean Society for Sexual Medicine and Andrology
2025-01-01
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| Series: | The World Journal of Men's Health |
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| author | Fausto Negri Luca Boeri Simone Cilio Edoardo Pozzi Federico Belladelli Christian Corsini Massimiliano Raffo Giuseppe Fallara Eugenio Ventimiglia Luigi Candela Alessia d’Arma Francesco Montorsi Andrea Salonia |
| author_facet | Fausto Negri Luca Boeri Simone Cilio Edoardo Pozzi Federico Belladelli Christian Corsini Massimiliano Raffo Giuseppe Fallara Eugenio Ventimiglia Luigi Candela Alessia d’Arma Francesco Montorsi Andrea Salonia |
| author_sort | Fausto Negri |
| collection | DOAJ |
| description | Purpose: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB).
Materials and Methods: Data from 1,230 consecutive men presenting for primary couple’s infertility were analyzed. Healthsignificant
comorbidities were scored with Charlson comorbidity index. Quartiles of FSH and InhB were considered to determine
threshold values. Descriptive statistics and logistic regression models tested association between FSH and InhB values.
Results: Overall, 1,080 (87.8%) men had concordant FSH and InhB values. Conversely, 150 patients (12.2%) had discrepancies
in FSH and InhB, with 78 (6.3%) and 72 (5.9%) men reporting both low and high FSH and InhB values, respectively.
Infertile men with discordant values were younger (median [interquartile range] 38.0 years [34–41 years] vs. 36.0 years [31–40
years]); had smaller testicular volume (TV) (12 mL [10–15 mL] vs. 15 mL [12–20 mL]); and, had more frequently a sperm
DNA fragmentation test >30% (179 [59.1%] vs. 40 [78.4%]) than those with concordant values (all p<0.05). Moreover, a
higher frequency of previous cryptorchidism (27.3% vs. 11.9%), lower sperm concentration (3.0 million/mL [0.9–11.0 million/
mL] vs. 13.8 million/mL [3.1–36.0 million/mL]), lower progressive sperm motility rates (12.0% [5.0%–25.3%] vs. 20.0%
[7.0%–36.0%]), and greater rates of non-obstructive azoospermia (36.4% vs. 23.9%) were found in men with discordant FSH
and InhB values (all p≤0.005). At multivariable logistic regression analysis, higher body mass index (odds ratio [OR], 1.08;
p=0.001), smaller TV (OR, 0.91; p<0.001), and a history of cryptorchidism (OR, 2.49; p<0.001) were associated with discordant
FSH and InhB values.
Conclusions: More than one out of ten infertile men had discordant FSH and InhB values in the real-life setting showing
worse clinical profiles than those with concordant levels. Smaller TV and history of cryptorchidism could be used as clinical
markers to better tailor the need to test InhB. |
| format | Article |
| id | doaj-art-4488ce7632e84b10ab996e29f512fcdf |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-4488ce7632e84b10ab996e29f512fcdf2025-01-03T03:14:19ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-01-0143113414110.5534/wjmh.230298The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional StudyFausto Negri0https://orcid.org/0000-0002-3677-6412Luca Boeri1https://orcid.org/0000-0003-0040-784XSimone Cilio2https://orcid.org/0000-0002-8431-9830Edoardo Pozzi3https://orcid.org/0000-0002-0228-7039Federico Belladelli4https://orcid.org/0000-0002-2165-659XChristian Corsini5https://orcid.org/0000-0001-9603-1589Massimiliano Raffo6https://orcid.org/0000-0001-6644-6521Giuseppe Fallara7https://orcid.org/0000-0001-7872-2650Eugenio Ventimiglia8https://orcid.org/0000-0003-3654-1629Luigi Candela9https://orcid.org/0000-0002-0593-8802Alessia d’Arma10https://orcid.org/0000-0002-4855-4577Francesco Montorsi11https://orcid.org/0000-0002-7267-4181Andrea Salonia12https://orcid.org/0000-0002-0595-7165Vita-Salute San Raffaele University, MilanDepartment of Urology, Foundation IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, MilanVita-Salute San Raffaele University, MilanVita-Salute San Raffaele University, MilanVita-Salute San Raffaele University, MilanVita-Salute San Raffaele University, MilanDivision of Experimental Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, MilanDivision of Experimental Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, MilanDivision of Experimental Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, MilanVita-Salute San Raffaele University, MilanDivision of Experimental Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, MilanVita-Salute San Raffaele University, MilanVita-Salute San Raffaele University, MilanPurpose: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB). Materials and Methods: Data from 1,230 consecutive men presenting for primary couple’s infertility were analyzed. Healthsignificant comorbidities were scored with Charlson comorbidity index. Quartiles of FSH and InhB were considered to determine threshold values. Descriptive statistics and logistic regression models tested association between FSH and InhB values. Results: Overall, 1,080 (87.8%) men had concordant FSH and InhB values. Conversely, 150 patients (12.2%) had discrepancies in FSH and InhB, with 78 (6.3%) and 72 (5.9%) men reporting both low and high FSH and InhB values, respectively. Infertile men with discordant values were younger (median [interquartile range] 38.0 years [34–41 years] vs. 36.0 years [31–40 years]); had smaller testicular volume (TV) (12 mL [10–15 mL] vs. 15 mL [12–20 mL]); and, had more frequently a sperm DNA fragmentation test >30% (179 [59.1%] vs. 40 [78.4%]) than those with concordant values (all p<0.05). Moreover, a higher frequency of previous cryptorchidism (27.3% vs. 11.9%), lower sperm concentration (3.0 million/mL [0.9–11.0 million/ mL] vs. 13.8 million/mL [3.1–36.0 million/mL]), lower progressive sperm motility rates (12.0% [5.0%–25.3%] vs. 20.0% [7.0%–36.0%]), and greater rates of non-obstructive azoospermia (36.4% vs. 23.9%) were found in men with discordant FSH and InhB values (all p≤0.005). At multivariable logistic regression analysis, higher body mass index (odds ratio [OR], 1.08; p=0.001), smaller TV (OR, 0.91; p<0.001), and a history of cryptorchidism (OR, 2.49; p<0.001) were associated with discordant FSH and InhB values. Conclusions: More than one out of ten infertile men had discordant FSH and InhB values in the real-life setting showing worse clinical profiles than those with concordant levels. Smaller TV and history of cryptorchidism could be used as clinical markers to better tailor the need to test InhB.follicle stimulating hormoneinfertility; maleinhibin breproductive healthsemen analysis |
| spellingShingle | Fausto Negri Luca Boeri Simone Cilio Edoardo Pozzi Federico Belladelli Christian Corsini Massimiliano Raffo Giuseppe Fallara Eugenio Ventimiglia Luigi Candela Alessia d’Arma Francesco Montorsi Andrea Salonia The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study The World Journal of Men's Health follicle stimulating hormone infertility; male inhibin b reproductive health semen analysis |
| title | The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study |
| title_full | The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study |
| title_fullStr | The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study |
| title_full_unstemmed | The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study |
| title_short | The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study |
| title_sort | importance of discordant follicle stimulating hormone and inhibin b levels in primary infertile men findings from a cross sectional study |
| topic | follicle stimulating hormone infertility; male inhibin b reproductive health semen analysis |
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