The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review
Chronic prostatitis/Chronic pelvis pain syndrome (CP/CPPS), a kind of frequent urinary condition among adult males, has caused a lot of inconvenience to patients in life, whose pathogenesis is unclear. Current evidence suggests that it is most likely to be an autoimmune disease. Symbiotic microbes,...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Microbiology |
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| author | An-Qi Deng An-Qi Deng An-Qi Deng An-Qi Deng Shao-Yu Yue Shao-Yu Yue Shao-Yu Yue Di Niu Di Niu Di Niu Dan-Dan Zhang Bing-Bing Hou Bing-Bing Hou Bing-Bing Hou Li Zhang Li Zhang Li Zhang Chao-Zhao Liang Chao-Zhao Liang Chao-Zhao Liang He-Xi Du He-Xi Du He-Xi Du |
| author_facet | An-Qi Deng An-Qi Deng An-Qi Deng An-Qi Deng Shao-Yu Yue Shao-Yu Yue Shao-Yu Yue Di Niu Di Niu Di Niu Dan-Dan Zhang Bing-Bing Hou Bing-Bing Hou Bing-Bing Hou Li Zhang Li Zhang Li Zhang Chao-Zhao Liang Chao-Zhao Liang Chao-Zhao Liang He-Xi Du He-Xi Du He-Xi Du |
| author_sort | An-Qi Deng |
| collection | DOAJ |
| description | Chronic prostatitis/Chronic pelvis pain syndrome (CP/CPPS), a kind of frequent urinary condition among adult males, has caused a lot of inconvenience to patients in life, whose pathogenesis is unclear. Current evidence suggests that it is most likely to be an autoimmune disease. Symbiotic microbes, a highly diverse biological community that harbors trillions of microbes in each region of the human body, have gradually made people realize their important role in immune regulation, material metabolism, and health maintenance. In recent years, increasing studies have shown a connection between microbiota and CP/CPPS. In view of this, we performed this review to summarize the literature pertaining to microbiota and its association with the pathophysiological mechanism of CP/CPPS. In addition, we gleaned the latest progress in the therapeutic strategy of CP/CPPS that related to microbiota regulation in order to offer new perspectives on the management of CP/CPPS. |
| format | Article |
| id | doaj-art-4487dc7a1ca4433ab2d5eabf39aba94c |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-4487dc7a1ca4433ab2d5eabf39aba94c2025-08-20T02:04:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-03-011610.3389/fmicb.2025.14887321488732The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a reviewAn-Qi Deng0An-Qi Deng1An-Qi Deng2An-Qi Deng3Shao-Yu Yue4Shao-Yu Yue5Shao-Yu Yue6Di Niu7Di Niu8Di Niu9Dan-Dan Zhang10Bing-Bing Hou11Bing-Bing Hou12Bing-Bing Hou13Li Zhang14Li Zhang15Li Zhang16Chao-Zhao Liang17Chao-Zhao Liang18Chao-Zhao Liang19He-Xi Du20He-Xi Du21He-Xi Du22Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaThe Second Clinical Medical School, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaClinical College of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, ChinaInstitute of Urology, Anhui Medical University, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, Anhui, ChinaChronic prostatitis/Chronic pelvis pain syndrome (CP/CPPS), a kind of frequent urinary condition among adult males, has caused a lot of inconvenience to patients in life, whose pathogenesis is unclear. Current evidence suggests that it is most likely to be an autoimmune disease. Symbiotic microbes, a highly diverse biological community that harbors trillions of microbes in each region of the human body, have gradually made people realize their important role in immune regulation, material metabolism, and health maintenance. In recent years, increasing studies have shown a connection between microbiota and CP/CPPS. In view of this, we performed this review to summarize the literature pertaining to microbiota and its association with the pathophysiological mechanism of CP/CPPS. In addition, we gleaned the latest progress in the therapeutic strategy of CP/CPPS that related to microbiota regulation in order to offer new perspectives on the management of CP/CPPS.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1488732/fullmicrobiotaCP/CPPSpathogenesistreatment microbiotatreatment |
| spellingShingle | An-Qi Deng An-Qi Deng An-Qi Deng An-Qi Deng Shao-Yu Yue Shao-Yu Yue Shao-Yu Yue Di Niu Di Niu Di Niu Dan-Dan Zhang Bing-Bing Hou Bing-Bing Hou Bing-Bing Hou Li Zhang Li Zhang Li Zhang Chao-Zhao Liang Chao-Zhao Liang Chao-Zhao Liang He-Xi Du He-Xi Du He-Xi Du The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review Frontiers in Microbiology microbiota CP/CPPS pathogenesis treatment microbiota treatment |
| title | The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review |
| title_full | The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review |
| title_fullStr | The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review |
| title_full_unstemmed | The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review |
| title_short | The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review |
| title_sort | role of microbiota in the chronic prostatitis chronic pelvis pain syndrome a review |
| topic | microbiota CP/CPPS pathogenesis treatment microbiota treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1488732/full |
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