Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas
Abstract Background Meningioma is a common primary central nervous system tumor that can cause a heavy burden on patients. Despite its well-established treatment modalities, pharmacological treatments are not sufficiently abundant. Therefore, we explored potential therapeutic targets for meningiomas...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03318-0 |
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| author | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Haoyu Shen Yi Guan |
| author_facet | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Haoyu Shen Yi Guan |
| author_sort | Yongxue Li |
| collection | DOAJ |
| description | Abstract Background Meningioma is a common primary central nervous system tumor that can cause a heavy burden on patients. Despite its well-established treatment modalities, pharmacological treatments are not sufficiently abundant. Therefore, we explored potential therapeutic targets for meningiomas by integrating genomic and proteomic data. Methods We integrated meningioma data from the UK Biobank and Finnish databases and subsequently explored potential therapeutic targets for meningiomas through multi-omics data using bioinformatics techniques and Mendelian randomization. These targets were finally evaluated using phenotype-wide association group analysis. Results We found that BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 can be potential therapeutic targets for meningiomas. Conclusion This study provides evidence and explores the biological significance of BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 as potential therapeutic targets for meningiomas, providing new insights into the development of targeted therapy for meningiomas. Graphical abstract |
| format | Article |
| id | doaj-art-4484696ff3bb41efa80440deb473e3db |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-4484696ff3bb41efa80440deb473e3db2025-08-20T03:43:22ZengSpringerDiscover Oncology2730-60112025-08-0116111510.1007/s12672-025-03318-0Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomasYongxue Li0Lihao Lin1Wenhui Zhang2Yan Wang3Haoyu Shen4Yi Guan5Department of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The Second Hospital of Tianjin Medical UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityAbstract Background Meningioma is a common primary central nervous system tumor that can cause a heavy burden on patients. Despite its well-established treatment modalities, pharmacological treatments are not sufficiently abundant. Therefore, we explored potential therapeutic targets for meningiomas by integrating genomic and proteomic data. Methods We integrated meningioma data from the UK Biobank and Finnish databases and subsequently explored potential therapeutic targets for meningiomas through multi-omics data using bioinformatics techniques and Mendelian randomization. These targets were finally evaluated using phenotype-wide association group analysis. Results We found that BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 can be potential therapeutic targets for meningiomas. Conclusion This study provides evidence and explores the biological significance of BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 as potential therapeutic targets for meningiomas, providing new insights into the development of targeted therapy for meningiomas. Graphical abstracthttps://doi.org/10.1007/s12672-025-03318-0Mendelian randomizationMeningiomaTherapeutic targetGenome-wide association study |
| spellingShingle | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Haoyu Shen Yi Guan Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas Discover Oncology Mendelian randomization Meningioma Therapeutic target Genome-wide association study |
| title | Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas |
| title_full | Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas |
| title_fullStr | Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas |
| title_full_unstemmed | Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas |
| title_short | Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas |
| title_sort | multi omics and mendelian randomization study explores potential therapeutic targets for meningiomas |
| topic | Mendelian randomization Meningioma Therapeutic target Genome-wide association study |
| url | https://doi.org/10.1007/s12672-025-03318-0 |
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