Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation
Abstract In this paper, we introduce a miniaturized intracardiac photoacoustic (PA) imaging system based on a phased-array intracardiac echocardiography catheter. This PA imaging system enhances imaging feedback during radiofrequency (RF) ablation for atrial fibrillation (A-fib) by providing ablatio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-98970-5 |
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| author | Shang Gao Yang Wang Ryo Murakami Hiroshi Ashikaga Young-Ho Kim Mohammad Mehrmohammadi Henry R. Halperin Haichong K. Zhang |
| author_facet | Shang Gao Yang Wang Ryo Murakami Hiroshi Ashikaga Young-Ho Kim Mohammad Mehrmohammadi Henry R. Halperin Haichong K. Zhang |
| author_sort | Shang Gao |
| collection | DOAJ |
| description | Abstract In this paper, we introduce a miniaturized intracardiac photoacoustic (PA) imaging system based on a phased-array intracardiac echocardiography catheter. This PA imaging system enhances imaging feedback during radiofrequency (RF) ablation for atrial fibrillation (A-fib) by providing ablation-induced lesion mapping. The PA imaging catheter with a 4-mm diameter was designed, featuring flexible tip for bending and navigation through the vessels. The catheter’s imaging resolution was evaluated using a phantom study with 0.2-mm-diameter wires. In an ex vivo study, the catheter was used to detect ablation-induced necrosis in porcine cardiac tissue, evaluating its capability to image through blood layer and differentiate necrotic tissue based on spectral characteristics. The catheter achieved an imaging resolution of 647.35 ± 61.60 µm in the phantom study. In the ex vivo study, it successfully identified necrotic lesions on porcine cardiac tissue, distinguishing these from surrounding tissue based on spectral analysis. The catheter system successfully imaged through an 8-mm blood layer, effectively highlighting necrotic regions. The proposed miniaturized PA imaging catheter demonstrated high-resolution imaging capability and effective detection of ablation-induced tissue boundary. Its flexibility and small diameter allow for maneuverability through cardiac vessels, enhancing its utility for intraoperative feedback during RF ablation procedures. This advancement offers a practical tool for improving the precision and effectiveness of RF ablation in A-fib treatment by integrating high-resolution imaging and maneuverability into a PA imaging catheter, potentially facilitating its adoption in clinical practice. |
| format | Article |
| id | doaj-art-4483e77406ea4a9797caaea6b4aefe42 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4483e77406ea4a9797caaea6b4aefe422025-08-20T03:08:40ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-98970-5Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablationShang Gao0Yang Wang1Ryo Murakami2Hiroshi Ashikaga3Young-Ho Kim4Mohammad Mehrmohammadi5Henry R. Halperin6Haichong K. Zhang7Department of Robotics Engineering, Worcester Polytechnic InstituteDepartment of Robotics Engineering, Worcester Polytechnic InstituteDepartment of Robotics Engineering, Worcester Polytechnic InstituteJohn A. Burns School of Medicine, University of HawaiiDigital Technology and Innovation, Siemens HealthineersDepartment of Imaging Sciences, University of Rochester Medical CenterDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDepartment of Robotics Engineering, Worcester Polytechnic InstituteAbstract In this paper, we introduce a miniaturized intracardiac photoacoustic (PA) imaging system based on a phased-array intracardiac echocardiography catheter. This PA imaging system enhances imaging feedback during radiofrequency (RF) ablation for atrial fibrillation (A-fib) by providing ablation-induced lesion mapping. The PA imaging catheter with a 4-mm diameter was designed, featuring flexible tip for bending and navigation through the vessels. The catheter’s imaging resolution was evaluated using a phantom study with 0.2-mm-diameter wires. In an ex vivo study, the catheter was used to detect ablation-induced necrosis in porcine cardiac tissue, evaluating its capability to image through blood layer and differentiate necrotic tissue based on spectral characteristics. The catheter achieved an imaging resolution of 647.35 ± 61.60 µm in the phantom study. In the ex vivo study, it successfully identified necrotic lesions on porcine cardiac tissue, distinguishing these from surrounding tissue based on spectral analysis. The catheter system successfully imaged through an 8-mm blood layer, effectively highlighting necrotic regions. The proposed miniaturized PA imaging catheter demonstrated high-resolution imaging capability and effective detection of ablation-induced tissue boundary. Its flexibility and small diameter allow for maneuverability through cardiac vessels, enhancing its utility for intraoperative feedback during RF ablation procedures. This advancement offers a practical tool for improving the precision and effectiveness of RF ablation in A-fib treatment by integrating high-resolution imaging and maneuverability into a PA imaging catheter, potentially facilitating its adoption in clinical practice.https://doi.org/10.1038/s41598-025-98970-5 |
| spellingShingle | Shang Gao Yang Wang Ryo Murakami Hiroshi Ashikaga Young-Ho Kim Mohammad Mehrmohammadi Henry R. Halperin Haichong K. Zhang Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation Scientific Reports |
| title | Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| title_full | Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| title_fullStr | Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| title_full_unstemmed | Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| title_short | Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| title_sort | miniaturized side firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation |
| url | https://doi.org/10.1038/s41598-025-98970-5 |
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