MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS
On laboratory animals received experimental model of hyperthyroidism. The experiment was conducted on 46 adult white male rats of Wistar weighing 250-300 g by administration of L-thyroxine in the dose 1,6 mg per 1 kg of body weight. In an experiment to determine the level of thyroid hormones and thy...
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2014-06-01
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| Series: | Кубанский научный медицинский вестник |
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| Online Access: | https://ksma.elpub.ru/jour/article/view/156 |
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| author | N. A. Stadnik V. S. Botasheva |
| author_facet | N. A. Stadnik V. S. Botasheva |
| author_sort | N. A. Stadnik |
| collection | DOAJ |
| description | On laboratory animals received experimental model of hyperthyroidism. The experiment was conducted on 46 adult white male rats of Wistar weighing 250-300 g by administration of L-thyroxine in the dose 1,6 mg per 1 kg of body weight. In an experiment to determine the level of thyroid hormones and thyroid stimulating hormone (TSH) in the blood, conducted histological examination of the thyroid gland. An increase in thyroid hormone levels in the blood of rats and correspondingly decrease TSH. Histological findings showed that the exogenous tiretoksikoze occurs morphological restructuring of the gland as in the parenchyma and stroma. In the parenchyma observed atrophy and deformation lobules downsizing tireotsitov and their nuclei, the violation ratio of small and large follicles and proliferative activity of the follicular epithelium. In the stroma glands develop sclerotic changes. Described histological changes confirmed by morphometric and immunohistochemical data showed a reduction in proliferation index (Ki- 67) and increased apoptotic index tireotsitov (P-53). |
| format | Article |
| id | doaj-art-44829cd50e15445da07257433260d8d8 |
| institution | Kabale University |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj-art-44829cd50e15445da07257433260d8d82025-08-20T03:57:21ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442014-06-013102108156MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSISN. A. Stadnik0V. S. Botasheva1state budget educational institution of higher professional education Stavropol state medical universitystate budget educational institution of higher professional education Stavropol state medical universityOn laboratory animals received experimental model of hyperthyroidism. The experiment was conducted on 46 adult white male rats of Wistar weighing 250-300 g by administration of L-thyroxine in the dose 1,6 mg per 1 kg of body weight. In an experiment to determine the level of thyroid hormones and thyroid stimulating hormone (TSH) in the blood, conducted histological examination of the thyroid gland. An increase in thyroid hormone levels in the blood of rats and correspondingly decrease TSH. Histological findings showed that the exogenous tiretoksikoze occurs morphological restructuring of the gland as in the parenchyma and stroma. In the parenchyma observed atrophy and deformation lobules downsizing tireotsitov and their nuclei, the violation ratio of small and large follicles and proliferative activity of the follicular epithelium. In the stroma glands develop sclerotic changes. Described histological changes confirmed by morphometric and immunohistochemical data showed a reduction in proliferation index (Ki- 67) and increased apoptotic index tireotsitov (P-53).https://ksma.elpub.ru/jour/article/view/156щитовидная железафолликулытиреоцитыкрысытиреотоксикозthyroid folliclesthyrocitesratsthyrotoxicosis |
| spellingShingle | N. A. Stadnik V. S. Botasheva MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS Кубанский научный медицинский вестник щитовидная железа фолликулы тиреоциты крысы тиреотоксикоз thyroid follicles thyrocites rats thyrotoxicosis |
| title | MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS |
| title_full | MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS |
| title_fullStr | MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS |
| title_full_unstemmed | MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS |
| title_short | MORPHOLOGY OF THE THYROID GLAND AT EXPERIMENTAL THYROTOXICOSIS |
| title_sort | morphology of the thyroid gland at experimental thyrotoxicosis |
| topic | щитовидная железа фолликулы тиреоциты крысы тиреотоксикоз thyroid follicles thyrocites rats thyrotoxicosis |
| url | https://ksma.elpub.ru/jour/article/view/156 |
| work_keys_str_mv | AT nastadnik morphologyofthethyroidglandatexperimentalthyrotoxicosis AT vsbotasheva morphologyofthethyroidglandatexperimentalthyrotoxicosis |