Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease
Background: The purpose of this study was to explore the clinical value and prognosis of the “prenatal diagnosis-postnatal treatment” model for fetuses with complex congenital heart disease (CHD) by directly comparing the outcomes between prenatal and postnatal diagnosis. Methods: A total of 126 inf...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806215 |
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| author | Shuyan Wu Le Chen Jianhui He Fengzhen Han Yanping Jiang |
| author_facet | Shuyan Wu Le Chen Jianhui He Fengzhen Han Yanping Jiang |
| author_sort | Shuyan Wu |
| collection | DOAJ |
| description | Background: The purpose of this study was to explore the clinical value and prognosis of the “prenatal diagnosis-postnatal treatment” model for fetuses with complex congenital heart disease (CHD) by directly comparing the outcomes between prenatal and postnatal diagnosis. Methods: A total of 126 infants with complex CHD diagnosed by prenatal diagnosis and 160 infants with complex CHD diagnosed by postnatal diagnosis in Guangdong Provincial People’s Hospital from January 2012 to December 2017 were enrolled in this retrospective study. The gestational age, birth weight, delivery mode, postpartum termination rate, qualified rate of follow-up assessment of pediatric heart surgery, postoperative complications, postoperative death, time of ventilator weaning, the length of postoperative hospital stay and prognosis were compared between the two groups. Results: There were no significant differences in delivery mode, premature birth rate, gestational age, birth weight, and mean maternal age between the two groups (p > 0.05). However, frequencies of terminating treatment after birth and postoperative complications were significantly higher in postnatal diagnosis group compared with prenatal diagnosis group (p< 0.05), while qualified rate of follow-up assessment of pediatric cardiac surgery was significantly lower in postnatal diagnosis group in comparison with prenatal diagnosis group (p < 0.05). Moreover, postoperative complication rate was significantly higher in the postnatal diagnosis group than prenatal diagnosis group (p < 0.05). Conclusion: Prenatal diagnosis can reduce postoperative complications after cardiac surgery and improve clinical prognosis for fetuses with complex CHD. |
| format | Article |
| id | doaj-art-4481ca7be2ec48acaf7b3172d08d1f2e |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-4481ca7be2ec48acaf7b3172d08d1f2e2025-08-20T02:05:51ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-12-014861358136210.31083/j.ceog4806215S0390-6663(21)01618-3Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart diseaseShuyan Wu0Le Chen1Jianhui He2Fengzhen Han3Yanping Jiang4Department of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, ChinaDepartment of Obstetrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, ChinaBackground: The purpose of this study was to explore the clinical value and prognosis of the “prenatal diagnosis-postnatal treatment” model for fetuses with complex congenital heart disease (CHD) by directly comparing the outcomes between prenatal and postnatal diagnosis. Methods: A total of 126 infants with complex CHD diagnosed by prenatal diagnosis and 160 infants with complex CHD diagnosed by postnatal diagnosis in Guangdong Provincial People’s Hospital from January 2012 to December 2017 were enrolled in this retrospective study. The gestational age, birth weight, delivery mode, postpartum termination rate, qualified rate of follow-up assessment of pediatric heart surgery, postoperative complications, postoperative death, time of ventilator weaning, the length of postoperative hospital stay and prognosis were compared between the two groups. Results: There were no significant differences in delivery mode, premature birth rate, gestational age, birth weight, and mean maternal age between the two groups (p > 0.05). However, frequencies of terminating treatment after birth and postoperative complications were significantly higher in postnatal diagnosis group compared with prenatal diagnosis group (p< 0.05), while qualified rate of follow-up assessment of pediatric cardiac surgery was significantly lower in postnatal diagnosis group in comparison with prenatal diagnosis group (p < 0.05). Moreover, postoperative complication rate was significantly higher in the postnatal diagnosis group than prenatal diagnosis group (p < 0.05). Conclusion: Prenatal diagnosis can reduce postoperative complications after cardiac surgery and improve clinical prognosis for fetuses with complex CHD.https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806215fetuscomplex congenital heart diseaseprenatal diagnosisclinical prognosis |
| spellingShingle | Shuyan Wu Le Chen Jianhui He Fengzhen Han Yanping Jiang Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease Clinical and Experimental Obstetrics & Gynecology fetus complex congenital heart disease prenatal diagnosis clinical prognosis |
| title | Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| title_full | Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| title_fullStr | Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| title_full_unstemmed | Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| title_short | Comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| title_sort | comparison of clinical prognosis between prenatal and postnatal diagnosis of fetuses with complex congenital heart disease |
| topic | fetus complex congenital heart disease prenatal diagnosis clinical prognosis |
| url | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806215 |
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