Influences of aqua-(2-formylbenzoato) triphenyltin(IV) on regression of hypoxic solid tumor through mitochondrial mediated pathway by inhibiting Hif-1 alpha

Influences of aqua-(2-formylbenzoato) triphenyltin(IV) on regression of hypoxic solid tumor through mitochondrial mediated pathway by inhibiting Hif-1 alpha

Abstract Tumor hypoxia is the major hindrance behind cancer chemotherapy and the foremost reason for the less effectiveness of most anticancer drugs. We herein inquire into the mechanistic part and therapeutic efficacy of our previously reported compound, aqua-(2-formylbenzoato) triphenyltin (IV) (a...

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Bibliographic Details
Main Authors: Virendra Singh, Ranjeet Singh, Pooja Goswami, Partha Pratim Manna, Tushar S. Basu Baul, Abhijit Mandal, Arvind Kumar Singh, Biplob Koch
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Solid tumor
Hypoxia
Apoptosis
Chemotherapy
Histopathology
Online Access:https://doi.org/10.1038/s41598-025-89761-z
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