Spontaneous splenic rupture in a patient with factor XIII deficiency: A case report

Spontaneous splenic rupture in a patient with factor XIII deficiency: A case report

Spontaneous splenic rupture is a rare, life-threatening event, infrequently associated with congenital factor XIII deficiency, a rare coagulation disorder. We present a case of an 18-year-old female with known factor XIII deficiency who presented with acute abdominal pain and was diagnosed with spon...

Full description

Saved in:
Bibliographic Details
Main Authors: José M. Zepeda Torres, MD, Essaú Brambila López, MD, Laura B. Alegría López, MD, Isac I. Ramírez Preciado, MD, Derek G. Cantú Ochoa, MD, Heriberto González Canal, MD, Héctor A. Benítez Jauregui, MD, Maria H. García Ramírez, MD, Daniel A. Ángel Montoya, MD, Carolina Topete Rodríguez, MD
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Radiology Case Reports
Subjects:
Spontaneous splenic rupture
Factor XIII deficiency
Coagulation disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043325005710
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spontaneous splenic rupture is a rare, life-threatening event, infrequently associated with congenital factor XIII deficiency, a rare coagulation disorder. We present a case of an 18-year-old female with known factor XIII deficiency who presented with acute abdominal pain and was diagnosed with spontaneous splenic rupture. The patient underwent splenectomy due to hemodynamic instability and massive hemorrhage. Postoperative management included factor XIII replacement and standard postsplenectomy prophylaxis. Spontaneous splenic rupture in the setting of factor XIII deficiency is exceedingly rare, with only a limited number of cases reported in the literature. This case highlights the importance of considering coagulation disorders in the differential diagnosis of atraumatic splenic rupture. Prompt diagnosis and multidisciplinary management, including surgical intervention when necessary, are critical for optimizing patient outcomes. This case underscores that factor XIII deficiency can lead to spontaneous life-threatening hemorrhage. Clinicians should maintain a high index of suspicion for this pathology in patients with known coagulopathies, and timely intervention is essential to improve patient outcomes. The importance of this approach is to quickly treat it when needed because is very deadly.
ISSN:1930-0433

Similar Items