Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia

Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia

Abstract Preleukemic stem cells (PSC) containing preleukemic fusion genes (PFG) arise prenatally and represent the initial stage of acute lymphoblastic leukemia (ALL) development. Despite widespread efforts, the cell of origin of PFG is still unclear. For the first time, in order to identify the imm...

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Main Authors: Katarina Vrobelova, Lukas Jakl, Milan Skorvaga, Pavol Kosik, Matus Durdik, Eva Markova, Jana Jakubikova, Marek Holop, Miroslav Kubes, Martin Cermak, Judita Puskacova, Alexandra Kolenova, Igor Belyaev
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-88204-z
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