Rickettsia sibirica mongolitimonae infection, Sri Lanka
Introduction. Rickettsia sibirica mongolitimonae was recently reported as a common rickettsiosis in France. Current serological evidence suggests the presence of scrub typhus and spotted fever group rickettsiosis in Sri Lanka. We detected a human case of R. sibirica mongolitimonae in Sri Lanka....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2017-09-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/8743 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850193358417297408 |
|---|---|
| author | Charlotte Cordier Pierre Tattevin Caroline Leyer Marine Cailleaux Didier Raoult Emmanouil Angelakis |
| author_facet | Charlotte Cordier Pierre Tattevin Caroline Leyer Marine Cailleaux Didier Raoult Emmanouil Angelakis |
| author_sort | Charlotte Cordier |
| collection | DOAJ |
| description |
Introduction. Rickettsia sibirica mongolitimonae was recently reported as a common rickettsiosis in France. Current serological evidence suggests the presence of scrub typhus and spotted fever group rickettsiosis in Sri Lanka. We detected a human case of R. sibirica mongolitimonae in Sri Lanka.
Methodology. A skin biopsy of the eschar was tested for the presence of Rickettsia spp. using qPCR assay targeting a 109-bp fragment of a hypothetical protein and by PCR amplification and sequencing targeting the ompA gene.
Results. A 30-year-old woman who had just returned from travel to a jungle in Sri Lanka was evaluated as an outpatient for fever. Examination revealed an enlarged axillary lymph node, a maculopapular rash and an eschar at her left flank and a skin biopsy of the eschar was performed. The skin biopsy was positive for the presence of Rickettsia spp. by qPCR and PCR amplification and sequencing targeting the ompA gene revealed R. sibirica mongolitimonae. Immunofluorescence assay on an acute serum sample for spotted fever group rickettsial antigens (Rickettsia conorii conorii, R. sibirica mongolitimonae, Rickettsia felis) and typhus group rickettsiae (Rickettsia typhi) was negative. The patient was treated by oral doxycycline (200 mg/day) for one week.
Conclusions. R. sibirica mongolitimonae should be considered in the differential diagnosis of patients with suspected rickettsiosis in, or returning from, Sri Lanka.
|
| format | Article |
| id | doaj-art-447334fc4aa04f2cb6a752957923ddc5 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-447334fc4aa04f2cb6a752957923ddc52025-08-20T02:14:17ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802017-09-01110810.3855/jidc.8743Rickettsia sibirica mongolitimonae infection, Sri LankaCharlotte Cordier0Pierre Tattevin1Caroline Leyer2Marine Cailleaux3Didier Raoult4Emmanouil Angelakis5URMITE CNRS-IRD 198 UMR 6236, Aix Marseille University, Marseille, FranceHospital Pontchaillou, Rennes, FranceHospital Pontchaillou, Rennes, FranceHospital Pontchaillou, Rennes, FranceURMITE CNRS-IRD 198 UMR 6236, Aix Marseille University, Marseille, FranceURMITE CNRS-IRD 198 UMR 6236, Aix Marseille University, Marseille, France Introduction. Rickettsia sibirica mongolitimonae was recently reported as a common rickettsiosis in France. Current serological evidence suggests the presence of scrub typhus and spotted fever group rickettsiosis in Sri Lanka. We detected a human case of R. sibirica mongolitimonae in Sri Lanka. Methodology. A skin biopsy of the eschar was tested for the presence of Rickettsia spp. using qPCR assay targeting a 109-bp fragment of a hypothetical protein and by PCR amplification and sequencing targeting the ompA gene. Results. A 30-year-old woman who had just returned from travel to a jungle in Sri Lanka was evaluated as an outpatient for fever. Examination revealed an enlarged axillary lymph node, a maculopapular rash and an eschar at her left flank and a skin biopsy of the eschar was performed. The skin biopsy was positive for the presence of Rickettsia spp. by qPCR and PCR amplification and sequencing targeting the ompA gene revealed R. sibirica mongolitimonae. Immunofluorescence assay on an acute serum sample for spotted fever group rickettsial antigens (Rickettsia conorii conorii, R. sibirica mongolitimonae, Rickettsia felis) and typhus group rickettsiae (Rickettsia typhi) was negative. The patient was treated by oral doxycycline (200 mg/day) for one week. Conclusions. R. sibirica mongolitimonae should be considered in the differential diagnosis of patients with suspected rickettsiosis in, or returning from, Sri Lanka. https://jidc.org/index.php/journal/article/view/8743Rickettsia sibirica mongolitimonaeskin biopsyrope-like lymphangitis-associated rickettsiosis |
| spellingShingle | Charlotte Cordier Pierre Tattevin Caroline Leyer Marine Cailleaux Didier Raoult Emmanouil Angelakis Rickettsia sibirica mongolitimonae infection, Sri Lanka Journal of Infection in Developing Countries Rickettsia sibirica mongolitimonae skin biopsy rope-like lymphangitis-associated rickettsiosis |
| title | Rickettsia sibirica mongolitimonae infection, Sri Lanka |
| title_full | Rickettsia sibirica mongolitimonae infection, Sri Lanka |
| title_fullStr | Rickettsia sibirica mongolitimonae infection, Sri Lanka |
| title_full_unstemmed | Rickettsia sibirica mongolitimonae infection, Sri Lanka |
| title_short | Rickettsia sibirica mongolitimonae infection, Sri Lanka |
| title_sort | rickettsia sibirica mongolitimonae infection sri lanka |
| topic | Rickettsia sibirica mongolitimonae skin biopsy rope-like lymphangitis-associated rickettsiosis |
| url | https://jidc.org/index.php/journal/article/view/8743 |
| work_keys_str_mv | AT charlottecordier rickettsiasibiricamongolitimonaeinfectionsrilanka AT pierretattevin rickettsiasibiricamongolitimonaeinfectionsrilanka AT carolineleyer rickettsiasibiricamongolitimonaeinfectionsrilanka AT marinecailleaux rickettsiasibiricamongolitimonaeinfectionsrilanka AT didierraoult rickettsiasibiricamongolitimonaeinfectionsrilanka AT emmanouilangelakis rickettsiasibiricamongolitimonaeinfectionsrilanka |