Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis
Introduction: Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief...
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| Format: | Article |
| Language: | English |
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Indian Orthopaedic Research Group
2025-03-01
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| Series: | Journal of Orthopaedic Case Reports |
| Subjects: | |
| Online Access: | https://jocr.co.in/wp/2025/03/01/effectiveness-of-platelet-rich-plasma-in-treating-rotator-cuff-tendinopathy-a-systematic-review-and-meta-analysis/ |
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| _version_ | 1849687950642642944 |
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| author | Mainak Roy Mulagondla Harshavardhan Reddy Deepanjan Das Priyanshu Denish Chandrakar A Muhil Elavarasu |
| author_facet | Mainak Roy Mulagondla Harshavardhan Reddy Deepanjan Das Priyanshu Denish Chandrakar A Muhil Elavarasu |
| author_sort | Mainak Roy |
| collection | DOAJ |
| description | Introduction:
Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief and tendon healing. This systematic review and meta-analysis evaluated PRP’s effectiveness compared to placebo or other treatments.
Materials and Methods:
A thorough search of PubMed, Embase, and Cochrane Library focused on randomized controlled trials (RCTs) using PRP as a primary intervention for rotator cuff tendinopathy. Eligible studies included pain reduction, functional improvement, and retear rates as outcomes. Data were extracted and analyzed using standardized methods.
Results:
Thirty RCTs with around 2,500 participants were included in the study. PRP significantly reduced pain and improved function in the short term compared to placebo and corticosteroids. However, long-term benefits (beyond 12 months) were limited, with retear rates and function similar to control groups.
Conclusion:
PRP provides significant short-term pain relief and functional improvement in rotator cuff tendinopathy but does not demonstrate superior long-term benefits over placebo or corticosteroids. |
| format | Article |
| id | doaj-art-4470da1f52be4f94a5e25b70aa47ee3a |
| institution | DOAJ |
| issn | 2250-0685 2321-3817 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Indian Orthopaedic Research Group |
| record_format | Article |
| series | Journal of Orthopaedic Case Reports |
| spelling | doaj-art-4470da1f52be4f94a5e25b70aa47ee3a2025-08-20T03:22:12ZengIndian Orthopaedic Research GroupJournal of Orthopaedic Case Reports2250-06852321-38172025-03-0115326527410.13107/jocr.2025.v15.i03.5408Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-AnalysisMainak RoyMulagondla Harshavardhan ReddyDeepanjan DasPriyanshuDenish ChandrakarA Muhil ElavarasuIntroduction: Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief and tendon healing. This systematic review and meta-analysis evaluated PRP’s effectiveness compared to placebo or other treatments. Materials and Methods: A thorough search of PubMed, Embase, and Cochrane Library focused on randomized controlled trials (RCTs) using PRP as a primary intervention for rotator cuff tendinopathy. Eligible studies included pain reduction, functional improvement, and retear rates as outcomes. Data were extracted and analyzed using standardized methods. Results: Thirty RCTs with around 2,500 participants were included in the study. PRP significantly reduced pain and improved function in the short term compared to placebo and corticosteroids. However, long-term benefits (beyond 12 months) were limited, with retear rates and function similar to control groups. Conclusion: PRP provides significant short-term pain relief and functional improvement in rotator cuff tendinopathy but does not demonstrate superior long-term benefits over placebo or corticosteroids.https://jocr.co.in/wp/2025/03/01/effectiveness-of-platelet-rich-plasma-in-treating-rotator-cuff-tendinopathy-a-systematic-review-and-meta-analysis/rotator cuff tendinopathyplatelet-rich plasmashoulder painregenerative therapymeta-analysis |
| spellingShingle | Mainak Roy Mulagondla Harshavardhan Reddy Deepanjan Das Priyanshu Denish Chandrakar A Muhil Elavarasu Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis Journal of Orthopaedic Case Reports rotator cuff tendinopathy platelet-rich plasma shoulder pain regenerative therapy meta-analysis |
| title | Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis |
| title_full | Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis |
| title_fullStr | Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis |
| title_short | Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis |
| title_sort | effectiveness of platelet rich plasma in treating rotator cuff tendinopathy a systematic review and meta analysis |
| topic | rotator cuff tendinopathy platelet-rich plasma shoulder pain regenerative therapy meta-analysis |
| url | https://jocr.co.in/wp/2025/03/01/effectiveness-of-platelet-rich-plasma-in-treating-rotator-cuff-tendinopathy-a-systematic-review-and-meta-analysis/ |
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