A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide

A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide

Abstract Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and continue to proliferate. While the geneti...

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Bibliographic Details
Main Authors: Pragyesh Dixit, Ilyas Djafer-Cherif, Saumil Shah, Karolina Drabik, Arne Traulsen, Bartlomiej Waclaw
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cancer
Glioblastoma
Temozolomide
Phenotypic heterogeneity
Mathematical modelling
Online Access:https://doi.org/10.1038/s41598-025-99426-6
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