Urinary bisphenol a concentration and angiography-defined coronary artery stenosis.
<h4>Background</h4>Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses.<h4>Methodology/principal findings</h4>To estimate associations...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043378&type=printable |
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| author | David Melzer Phil Gates Nicholas J Osborne William E Henley Ricardo Cipelli Anita Young Cathryn Money Paul McCormack Peter Schofield David Mosedale David Grainger Tamara S Galloway |
| author_facet | David Melzer Phil Gates Nicholas J Osborne William E Henley Ricardo Cipelli Anita Young Cathryn Money Paul McCormack Peter Schofield David Mosedale David Grainger Tamara S Galloway |
| author_sort | David Melzer |
| collection | DOAJ |
| description | <h4>Background</h4>Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses.<h4>Methodology/principal findings</h4>To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. Linear models were adjusted for BMI, occupational social class and diabetes status. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n=86) and 120 had normal coronary arteries. The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD=5.96 ng/ml OR=1.43, CI 1.03 to 1.98, p=0.033), and near significant for intermediate disease (OR=1.69, CI 0.98 to 2.94, p=0.061). There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined.<h4>Conclusions/significance</h4>BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established. |
| format | Article |
| id | doaj-art-446f5bd586ce4bc18dc1db1e7242f6b5 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-446f5bd586ce4bc18dc1db1e7242f6b52025-08-20T03:26:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4337810.1371/journal.pone.0043378Urinary bisphenol a concentration and angiography-defined coronary artery stenosis.David MelzerPhil GatesNicholas J OsborneWilliam E HenleyRicardo CipelliAnita YoungCathryn MoneyPaul McCormackPeter SchofieldDavid MosedaleDavid GraingerTamara S Galloway<h4>Background</h4>Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses.<h4>Methodology/principal findings</h4>To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. Linear models were adjusted for BMI, occupational social class and diabetes status. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n=86) and 120 had normal coronary arteries. The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD=5.96 ng/ml OR=1.43, CI 1.03 to 1.98, p=0.033), and near significant for intermediate disease (OR=1.69, CI 0.98 to 2.94, p=0.061). There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined.<h4>Conclusions/significance</h4>BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043378&type=printable |
| spellingShingle | David Melzer Phil Gates Nicholas J Osborne William E Henley Ricardo Cipelli Anita Young Cathryn Money Paul McCormack Peter Schofield David Mosedale David Grainger Tamara S Galloway Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. PLoS ONE |
| title | Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. |
| title_full | Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. |
| title_fullStr | Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. |
| title_full_unstemmed | Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. |
| title_short | Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. |
| title_sort | urinary bisphenol a concentration and angiography defined coronary artery stenosis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043378&type=printable |
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