Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study
Background: Blood glucose and serum albumin can be biomarkers at admission since they are easily accessible and demonstrate correlations with cardiovascular diseases. The predictive ability of the admission blood glucose to albumin ratio (AAR) for long-term prognosis in patients w...
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IMR Press
2025-04-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/4/10.31083/RCM26567 |
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| author | Maoling Jiang Qiang Chen Qiao Feng Xiufen Peng Juan Liu Hui He Hong Su Dongyue Jia Lin Tong Jing Tian Shiqiang Xiong Lin Cai |
| author_facet | Maoling Jiang Qiang Chen Qiao Feng Xiufen Peng Juan Liu Hui He Hong Su Dongyue Jia Lin Tong Jing Tian Shiqiang Xiong Lin Cai |
| author_sort | Maoling Jiang |
| collection | DOAJ |
| description | Background: Blood glucose and serum albumin can be biomarkers at admission since they are easily accessible and demonstrate correlations with cardiovascular diseases. The predictive ability of the admission blood glucose to albumin ratio (AAR) for long-term prognosis in patients with acute coronary syndrome (ACS) and its potential to elevate the predictive value of the Global Registry of Acute Coronary Events (GRACE) risk score in ACS patients post-percutaneous coronary intervention (PCI) remains unknown. Hence, this study aimed to investigate the incremental prognostic value of the AAR in patients with ACS undergoing PCI. Methods: A rigorous development-validation approach was implemented to optimize the GRACE risk score, utilizing the AAR parameter in 1498 patients suffering from ACS after PCI at the Third People’s Hospital of Chengdu, Sichuan, China. Results: Over a median of 31.25 (27.53, 35.10) months, the incidence of major adverse cardiac events (MACEs), defined as a composite outcome encompassing all-cause death, cardiac death, nonfatal myocardial infarction, nonfatal stroke, and unplanned repeat revascularization, was higher in individuals with higher AARs. Thus, the AAR was an independent predictor of long-term prognosis in ACS patients undergoing PCI (HR, 1.145; 95% CI: 1.045–1.255; p = 0.004). The integration of the AAR score with the GRACE risk score increased the C statistic from 0.717 (95% CI: 0.694–0.740) to 0.733 (95% CI: 0.690–0.776) (p < 0.01). Conclusions: The AAR is an independent predictor of prognosis in ACS patients and significantly increased the predictive value of the GRACE risk score. |
| format | Article |
| id | doaj-art-446f32a42a5943279af332fdd1cd881e |
| institution | OA Journals |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-446f32a42a5943279af332fdd1cd881e2025-08-20T01:48:21ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-04-012642656710.31083/RCM26567S1530-6550(24)01724-1Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort StudyMaoling Jiang0Qiang Chen1Qiao Feng2Xiufen Peng3Juan Liu4Hui He5Hong Su6Dongyue Jia7Lin Tong8Jing Tian9Shiqiang Xiong10Lin Cai11Department of Cardiology, Affiliated Hospital, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, ChinaDepartment of Cardiology, Affiliated Hospital, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Cardiology, Affiliated Hospital, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu, 610014 Chengdu, Sichuan, ChinaDepartment of Cardiology, Affiliated Hospital, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaBackground: Blood glucose and serum albumin can be biomarkers at admission since they are easily accessible and demonstrate correlations with cardiovascular diseases. The predictive ability of the admission blood glucose to albumin ratio (AAR) for long-term prognosis in patients with acute coronary syndrome (ACS) and its potential to elevate the predictive value of the Global Registry of Acute Coronary Events (GRACE) risk score in ACS patients post-percutaneous coronary intervention (PCI) remains unknown. Hence, this study aimed to investigate the incremental prognostic value of the AAR in patients with ACS undergoing PCI. Methods: A rigorous development-validation approach was implemented to optimize the GRACE risk score, utilizing the AAR parameter in 1498 patients suffering from ACS after PCI at the Third People’s Hospital of Chengdu, Sichuan, China. Results: Over a median of 31.25 (27.53, 35.10) months, the incidence of major adverse cardiac events (MACEs), defined as a composite outcome encompassing all-cause death, cardiac death, nonfatal myocardial infarction, nonfatal stroke, and unplanned repeat revascularization, was higher in individuals with higher AARs. Thus, the AAR was an independent predictor of long-term prognosis in ACS patients undergoing PCI (HR, 1.145; 95% CI: 1.045–1.255; p = 0.004). The integration of the AAR score with the GRACE risk score increased the C statistic from 0.717 (95% CI: 0.694–0.740) to 0.733 (95% CI: 0.690–0.776) (p < 0.01). Conclusions: The AAR is an independent predictor of prognosis in ACS patients and significantly increased the predictive value of the GRACE risk score.https://www.imrpress.com/journal/RCM/26/4/10.31083/RCM26567grace scoreadmission blood glucosealbuminpercutaneous coronary interventionacute coronary syndromeprognosis |
| spellingShingle | Maoling Jiang Qiang Chen Qiao Feng Xiufen Peng Juan Liu Hui He Hong Su Dongyue Jia Lin Tong Jing Tian Shiqiang Xiong Lin Cai Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study Reviews in Cardiovascular Medicine grace score admission blood glucose albumin percutaneous coronary intervention acute coronary syndrome prognosis |
| title | Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study |
| title_full | Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study |
| title_fullStr | Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study |
| title_full_unstemmed | Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study |
| title_short | Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study |
| title_sort | incremental prognostic value of admission blood glucose to albumin ratio in patients with acute coronary syndrome a retrospective observational cohort study |
| topic | grace score admission blood glucose albumin percutaneous coronary intervention acute coronary syndrome prognosis |
| url | https://www.imrpress.com/journal/RCM/26/4/10.31083/RCM26567 |
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