Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1–STAT3 signaling

Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1–STAT3 signaling

IntroductionParasites and parasite-derived extracellular vesicles (EVs) and microRNAs (miRNAs) can protect against inflammatory diseases, such as asthma. M2a macrophages facilitate the development of allergic asthma. miR-10a-5p is closely associated with asthma, and emu-miR-10a-5p (encapsulated in E...

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Bibliographic Details
Main Authors: Yunzhuo Xin, Rou Wen, Dong Song, Jing Xiao, Xiaoping Gao, Mei Yin, Yanli Bai, Jie Wang, Xiangyu Zhou, Jiaqing Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
asthma
extracellular vesicle
leukemia inhibitory factor (LIF)
M2a macrophage
emu-miRNA-10a-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577349/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577349/full

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