Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review
<b>Background/Objectives</b>: Uric acid stones are the second most common type of kidney stones worldwide. Despite being cost-effective and widely available, pharmacological management for these stones is less utilized compared to surgical approaches. Therefore, we conducted a systematic...
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MDPI AG
2024-08-01
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| Series: | Société Internationale d’Urologie Journal |
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| Online Access: | https://www.mdpi.com/2563-6499/5/4/47 |
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| author | Ava Mousavi Rebecca Takele Bree’ava Limbrick Karan N. Thaker Kymora B. Scotland |
| author_facet | Ava Mousavi Rebecca Takele Bree’ava Limbrick Karan N. Thaker Kymora B. Scotland |
| author_sort | Ava Mousavi |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Uric acid stones are the second most common type of kidney stones worldwide. Despite being cost-effective and widely available, pharmacological management for these stones is less utilized compared to surgical approaches. Therefore, we conducted a systematic review of the literature to assess the efficacy and shortcomings of oral dissolution therapy for uric acid stones. <b>Methods</b>: Embase, Scopus, PubMed, and Cochrane library databases were searched for English language studies on adults who were diagnosed with uric acid kidney stones and treated with oral dissolution therapy. <b>Results</b>: Twelve studies met our inclusion criteria. Potassium citrate was the primary agent used for dissolution in 10 of the studies and demonstrated a 50% or higher success rate for complete dissolution of uric acid stones. Treatment time for successful dissolution varied, with an average of 3 months minimum and an average of 2.78 years maximum. Overall, 11 of the studies recommended that oral dissolution therapy should be used for either treatment or prevention of uric acid stones. <b>Conclusions</b>: The available evidence demonstrates benefit of oral dissolution therapy for patients with uric acid stones. However, future rigorous studies are required to determine the optimal treatment regimen. |
| format | Article |
| id | doaj-art-44698aec4d4247c9b7b377dffb3632a7 |
| institution | Kabale University |
| issn | 2563-6499 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Société Internationale d’Urologie Journal |
| spelling | doaj-art-44698aec4d4247c9b7b377dffb3632a72025-08-20T03:36:06ZengMDPI AGSociété Internationale d’Urologie Journal2563-64992024-08-015428429910.3390/siuj5040047Oral Dissolution Therapy of Uric Acid Stones: A Systematic ReviewAva Mousavi0Rebecca Takele1Bree’ava Limbrick2Karan N. Thaker3Kymora B. Scotland4Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USASUNY Downstate Department of Orthopaedic Surgery and Rehabilitation Medicine, Brooklyn, NY 11203, USADepartment of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA<b>Background/Objectives</b>: Uric acid stones are the second most common type of kidney stones worldwide. Despite being cost-effective and widely available, pharmacological management for these stones is less utilized compared to surgical approaches. Therefore, we conducted a systematic review of the literature to assess the efficacy and shortcomings of oral dissolution therapy for uric acid stones. <b>Methods</b>: Embase, Scopus, PubMed, and Cochrane library databases were searched for English language studies on adults who were diagnosed with uric acid kidney stones and treated with oral dissolution therapy. <b>Results</b>: Twelve studies met our inclusion criteria. Potassium citrate was the primary agent used for dissolution in 10 of the studies and demonstrated a 50% or higher success rate for complete dissolution of uric acid stones. Treatment time for successful dissolution varied, with an average of 3 months minimum and an average of 2.78 years maximum. Overall, 11 of the studies recommended that oral dissolution therapy should be used for either treatment or prevention of uric acid stones. <b>Conclusions</b>: The available evidence demonstrates benefit of oral dissolution therapy for patients with uric acid stones. However, future rigorous studies are required to determine the optimal treatment regimen.https://www.mdpi.com/2563-6499/5/4/47uric acidurolithiasisoral dissolution therapypotassium citratesodium bicarbonate |
| spellingShingle | Ava Mousavi Rebecca Takele Bree’ava Limbrick Karan N. Thaker Kymora B. Scotland Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review Société Internationale d’Urologie Journal uric acid urolithiasis oral dissolution therapy potassium citrate sodium bicarbonate |
| title | Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review |
| title_full | Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review |
| title_fullStr | Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review |
| title_full_unstemmed | Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review |
| title_short | Oral Dissolution Therapy of Uric Acid Stones: A Systematic Review |
| title_sort | oral dissolution therapy of uric acid stones a systematic review |
| topic | uric acid urolithiasis oral dissolution therapy potassium citrate sodium bicarbonate |
| url | https://www.mdpi.com/2563-6499/5/4/47 |
| work_keys_str_mv | AT avamousavi oraldissolutiontherapyofuricacidstonesasystematicreview AT rebeccatakele oraldissolutiontherapyofuricacidstonesasystematicreview AT breeavalimbrick oraldissolutiontherapyofuricacidstonesasystematicreview AT karannthaker oraldissolutiontherapyofuricacidstonesasystematicreview AT kymorabscotland oraldissolutiontherapyofuricacidstonesasystematicreview |