Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020
BackgroundThe weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).MethodThe data of 44,528 participants in total were gathered from NHANES database fro...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1445802/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546624651755520 |
|---|---|
| author | Yan Liu Shougang Sun Qi Zou Ting Tao Dian Li Guodong Han Zhiliang Wei |
| author_facet | Yan Liu Shougang Sun Qi Zou Ting Tao Dian Li Guodong Han Zhiliang Wei |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | BackgroundThe weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).MethodThe data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020. WWI is calculated as the waist circumference (WC, cm) divided by the square root of the body weight (kg), and CHD was determined based on participants’ self-reports. The association between WWI and CHD was examined using multiple logistic regression analysis, restrictive cubic spline (RCS), receiver operating characteristic (ROC) curve, mediation analysis, subgroup and interaction analyses.ResultThis was a cross-sectional investigation. A total of 44,528 participants were included [50.23% male; mean WWI 10.89 (0.01) cm/√kg]. The multivariate logistic regression analysis revealed that in three models, one-standard-deviation increment in WWI was associated with an increased probability of CHD occurrence by 2.39 (2.22,2.57),1.47 (1.32,1.65), and 1.15 (1.00,1.32) times, respectively. Additionally, RCS analysis indicated a linear relationship between WWI and CHD. and the ROC analysis results showed that the discriminatory power of WWI for CHD was superior to that of body mass index (BMI) and WC. Glycated hemoglobin (HbA1c) partially mediated the relationship between WWI and CHD. Subgroup and interaction analyses confirmed that age, systolic blood pressure, and diabetes status had a significant impact on the association between WWI and CHD (P for interaction <0.05).ConclusionThe level of WWI has been demonstrated to be associated with an increased risk of CHD. Specifically, as WWI increases, the risk of CHD becomes higher. On this basis, it is hypothesized that WWI may potentially serve as an independent risk factor for CAD, thereby highlighting the substantial value of WWI in the identification and management of CHD. |
| format | Article |
| id | doaj-art-4469592e64c64f209e845dc0dbfe1453 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4469592e64c64f209e845dc0dbfe14532025-01-10T16:06:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14458021445802Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020Yan Liu0Shougang Sun1Qi Zou2Ting Tao3Dian Li4Guodong Han5Zhiliang Wei6The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of Cardiology, The Second Hospital of Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of Cardiology, The Second Hospital of Lanzhou University, Lanzhou, ChinaBackgroundThe weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).MethodThe data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020. WWI is calculated as the waist circumference (WC, cm) divided by the square root of the body weight (kg), and CHD was determined based on participants’ self-reports. The association between WWI and CHD was examined using multiple logistic regression analysis, restrictive cubic spline (RCS), receiver operating characteristic (ROC) curve, mediation analysis, subgroup and interaction analyses.ResultThis was a cross-sectional investigation. A total of 44,528 participants were included [50.23% male; mean WWI 10.89 (0.01) cm/√kg]. The multivariate logistic regression analysis revealed that in three models, one-standard-deviation increment in WWI was associated with an increased probability of CHD occurrence by 2.39 (2.22,2.57),1.47 (1.32,1.65), and 1.15 (1.00,1.32) times, respectively. Additionally, RCS analysis indicated a linear relationship between WWI and CHD. and the ROC analysis results showed that the discriminatory power of WWI for CHD was superior to that of body mass index (BMI) and WC. Glycated hemoglobin (HbA1c) partially mediated the relationship between WWI and CHD. Subgroup and interaction analyses confirmed that age, systolic blood pressure, and diabetes status had a significant impact on the association between WWI and CHD (P for interaction <0.05).ConclusionThe level of WWI has been demonstrated to be associated with an increased risk of CHD. Specifically, as WWI increases, the risk of CHD becomes higher. On this basis, it is hypothesized that WWI may potentially serve as an independent risk factor for CAD, thereby highlighting the substantial value of WWI in the identification and management of CHD.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1445802/fullweight adjusted waist indexcoronary heart diseaseNHANESobesityepidemiology |
| spellingShingle | Yan Liu Shougang Sun Qi Zou Ting Tao Dian Li Guodong Han Zhiliang Wei Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 Frontiers in Cardiovascular Medicine weight adjusted waist index coronary heart disease NHANES obesity epidemiology |
| title | Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 |
| title_full | Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 |
| title_fullStr | Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 |
| title_full_unstemmed | Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 |
| title_short | Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020 |
| title_sort | correlation between weight adjusted waist index and coronary heart disease nhanes 1999 2020 |
| topic | weight adjusted waist index coronary heart disease NHANES obesity epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1445802/full |
| work_keys_str_mv | AT yanliu correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT shougangsun correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT qizou correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT tingtao correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT dianli correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT guodonghan correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 AT zhiliangwei correlationbetweenweightadjustedwaistindexandcoronaryheartdiseasenhanes19992020 |