Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive symptoms, underscoring the urgent need for predictive blood biomarkers. Plasma extracellular vesicles (EVs) offer a promising platform for biomarker development, with neurofilament light chain (NfL) emergin...
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| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2024-12-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11502 |
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| author | Chien-Tai Hong Chen‐Chih Chung Yi-Chen Hsieh Lung Chan |
| author_facet | Chien-Tai Hong Chen‐Chih Chung Yi-Chen Hsieh Lung Chan |
| author_sort | Chien-Tai Hong |
| collection | DOAJ |
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Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive symptoms, underscoring the urgent need for predictive blood biomarkers. Plasma extracellular vesicles (EVs) offer a promising platform for biomarker development, with neurofilament light chain (NfL) emerging as a potential candidate for neurological diseases. This study evaluated plasma EV NfL as a biomarker for disease progression in a PD cohort.A total of 55 patients with PD (PwP) and 58 healthy controls (HCs) were followed, with PwP completing an average of 3.96 visits and HCs 2.25 visits. Plasma EVs were isolated and validated, and EV NfL levels were measured using an immunomagnetic reduction assay. Generalized estimating equations and Spearman correlations assessed relationships between clinical symptom progression and biomarkers. Although no significant differences in plasma EV NfL levels were observed between PwP and HCs over time, changes in plasma EV NfL significantly correlated with motor symptom progression, specifically with adjusted-total and akinetic-rigidity subscores of the Unified PD Rating Scale (UPDRS) Part III. Additionally, changes in UPDRS Part II scores were significantly associated with plasma EV NfL levels. These findings suggest that plasma EV NfL reflects motor symptom progression in PwP, highlighting its potential as a valuable biomarker for monitoring disease progression and guiding clinical trials in PD.
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| format | Article |
| id | doaj-art-4468670ae4f24e0fb16c6cc5fbbca560 |
| institution | OA Journals |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-4468670ae4f24e0fb16c6cc5fbbca5602025-08-20T01:56:10ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2024-12-0110.17305/bb.2024.11502Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s diseaseChien-Tai Hong0Chen‐Chih Chung1Yi-Chen Hsieh2Lung Chan3Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanCollege of Medical Science and Technology, Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive symptoms, underscoring the urgent need for predictive blood biomarkers. Plasma extracellular vesicles (EVs) offer a promising platform for biomarker development, with neurofilament light chain (NfL) emerging as a potential candidate for neurological diseases. This study evaluated plasma EV NfL as a biomarker for disease progression in a PD cohort.A total of 55 patients with PD (PwP) and 58 healthy controls (HCs) were followed, with PwP completing an average of 3.96 visits and HCs 2.25 visits. Plasma EVs were isolated and validated, and EV NfL levels were measured using an immunomagnetic reduction assay. Generalized estimating equations and Spearman correlations assessed relationships between clinical symptom progression and biomarkers. Although no significant differences in plasma EV NfL levels were observed between PwP and HCs over time, changes in plasma EV NfL significantly correlated with motor symptom progression, specifically with adjusted-total and akinetic-rigidity subscores of the Unified PD Rating Scale (UPDRS) Part III. Additionally, changes in UPDRS Part II scores were significantly associated with plasma EV NfL levels. These findings suggest that plasma EV NfL reflects motor symptom progression in PwP, highlighting its potential as a valuable biomarker for monitoring disease progression and guiding clinical trials in PD. https://www.bjbms.org/ojs/index.php/bjbms/article/view/11502Parkinson’s diseasePDextracellular vesicleEVbiomarkersneurofilament light chain |
| spellingShingle | Chien-Tai Hong Chen‐Chih Chung Yi-Chen Hsieh Lung Chan Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease Biomolecules & Biomedicine Parkinson’s disease PD extracellular vesicle EV biomarkers neurofilament light chain |
| title | Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease |
| title_full | Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease |
| title_fullStr | Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease |
| title_full_unstemmed | Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease |
| title_short | Plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of Parkinson’s disease |
| title_sort | plasma extracellular vesicle neurofilament light chain as the biomarkers of the progression of parkinson s disease |
| topic | Parkinson’s disease PD extracellular vesicle EV biomarkers neurofilament light chain |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11502 |
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