Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market
<b>Aim: </b>This study was performed to re-evaluate the efficacy of the combination oxfendazole+oxyclozanide, after thirty years of its introduction into the Turkish antiparasitic drug market.<p> <b>Materials and Methods: </b>In this study, 32 sheep infected with gastro...
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| Language: | English |
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Selcuk University Press
2020-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1327 |
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| author | Onur Ceylan Uğur Uslu Ceylan Ceylan Abdullah Küçükyağlıoğlu Bayram Şenlik |
| author_facet | Onur Ceylan Uğur Uslu Ceylan Ceylan Abdullah Küçükyağlıoğlu Bayram Şenlik |
| author_sort | Onur Ceylan |
| collection | DOAJ |
| description | <b>Aim: </b>This study was performed to re-evaluate the efficacy of the combination
oxfendazole+oxyclozanide, after thirty years of its introduction into the Turkish
antiparasitic drug market.<p>
<b>Materials and Methods: </b>In this study, 32 sheep infected with gastrointestinal
nematodes were used. Sheep were selected on the basis of the number of eggs
in one gram of their fecal sample. Sheep selected were divided into two groups:
group I, sheep were treated orally at day zero, with oxfendazole+oxyclozanide
combination at a dose rate of 7.5 mg/kg and 15 mg/kg of body weight, respectively;
group II, sheep were used as untreated controls. Fecal samples were
collected from each sheep on day 1 of their treatment, and on days 7, 14, and
21 of post-treatment. To determine the anthelmintic drug treatment?s efficacy,
individual sheep?s fecal egg count per gram of feces was determined by performing
McMaster method and fecal egg count reduction test.<p>
<b>Results:</b> Fecal egg counts of these two groups were statistically not different
on the day of treatment. At day 7 of post-treatment, few eggs were detected
only in one sheep, and the mean of fecal egg counts of the treatment group was
66.7 ±66.7. On days 14 and 21 of post-treatment, fecal egg counts decreased
to zero in the treatment group but significantly did not change in the control
group. The efficacy of the combination was found to be 100% at day 14 and 21
of post-treatment.<p>
<b>Conclusion:</b> This study revealed that the combination
oxfendazole+oxyclozanide was highly effective against the gastrointestinal
nematodes in sheep. |
| format | Article |
| id | doaj-art-4467a2d690364e07baf67bd13a733eee |
| institution | DOAJ |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-4467a2d690364e07baf67bd13a733eee2025-08-20T02:52:06ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532020-12-013642552601327Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug marketOnur Ceylan0Uğur Uslu1Ceylan Ceylan2Abdullah Küçükyağlıoğlu3Bayram Şenlik4Selcuk University, Veterinary Faculty, Department of Parasitology, Konya, TurkeySelcuk University, Medicine Faculty, Department of Medical Microbiology,, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Parasitology, Konya, TurkeySelcuklu Municipality, Department of Agriculture and Animal Services, Konya, TurkeyUludag University, Veterinary Faculty, Department of Parasitology, Bursa, Turkey<b>Aim: </b>This study was performed to re-evaluate the efficacy of the combination oxfendazole+oxyclozanide, after thirty years of its introduction into the Turkish antiparasitic drug market.<p> <b>Materials and Methods: </b>In this study, 32 sheep infected with gastrointestinal nematodes were used. Sheep were selected on the basis of the number of eggs in one gram of their fecal sample. Sheep selected were divided into two groups: group I, sheep were treated orally at day zero, with oxfendazole+oxyclozanide combination at a dose rate of 7.5 mg/kg and 15 mg/kg of body weight, respectively; group II, sheep were used as untreated controls. Fecal samples were collected from each sheep on day 1 of their treatment, and on days 7, 14, and 21 of post-treatment. To determine the anthelmintic drug treatment?s efficacy, individual sheep?s fecal egg count per gram of feces was determined by performing McMaster method and fecal egg count reduction test.<p> <b>Results:</b> Fecal egg counts of these two groups were statistically not different on the day of treatment. At day 7 of post-treatment, few eggs were detected only in one sheep, and the mean of fecal egg counts of the treatment group was 66.7 ±66.7. On days 14 and 21 of post-treatment, fecal egg counts decreased to zero in the treatment group but significantly did not change in the control group. The efficacy of the combination was found to be 100% at day 14 and 21 of post-treatment.<p> <b>Conclusion:</b> This study revealed that the combination oxfendazole+oxyclozanide was highly effective against the gastrointestinal nematodes in sheep.http://eurasianjvetsci.org/pdf.php3?id=1327nematodeoxfendazoleoxyclozanidesheeptrichostrong |
| spellingShingle | Onur Ceylan Uğur Uslu Ceylan Ceylan Abdullah Küçükyağlıoğlu Bayram Şenlik Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market Eurasian Journal of Veterinary Sciences nematode oxfendazole oxyclozanide sheep trichostrong |
| title | Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market |
| title_full | Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market |
| title_fullStr | Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market |
| title_full_unstemmed | Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market |
| title_short | Re-evaluation of the efficacy of oxfendazole+oxyclozanide combination against gastrointestinal nematodes in sheep, a long time after the introduction into the turkish antiparasitic drug market |
| title_sort | re evaluation of the efficacy of oxfendazole oxyclozanide combination against gastrointestinal nematodes in sheep a long time after the introduction into the turkish antiparasitic drug market |
| topic | nematode oxfendazole oxyclozanide sheep trichostrong |
| url | http://eurasianjvetsci.org/pdf.php3?id=1327 |
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