Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management
Granulosa cell tumors (GCTs) of the testis are rare sex cord-stromal tumors that are present in both juvenile and adult subtypes. While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2016/9016728 |
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| author | Anand Mohapatra Aaron M. Potretzke Brent A. Knight Min Han Robert S. Figenshau |
| author_facet | Anand Mohapatra Aaron M. Potretzke Brent A. Knight Min Han Robert S. Figenshau |
| author_sort | Anand Mohapatra |
| collection | DOAJ |
| description | Granulosa cell tumors (GCTs) of the testis are rare sex cord-stromal tumors that are present in both juvenile and adult subtypes. While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options that have been employed in previous cases include retroperitoneal lymph node dissection (RPLND), radiation, chemotherapy, or a combination thereof. We describe the case of a 57-year-old man who presented with a painless left testicular mass and painful gynecomastia. Serum tumor markers (alpha fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase) and computed tomography of the chest and abdomen were negative. The patient underwent left radical orchiectomy. Immunohistochemical staining was consistent with a testicular GCT. He underwent a left-template laparoscopic RPLND which revealed 2/19 positive lymph nodes. Final pathological stage was IIA. He remains free of disease 32 months after surgery. |
| format | Article |
| id | doaj-art-4463b39cd4ec41df9d7d520423c54faa |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-4463b39cd4ec41df9d7d520423c54faa2025-02-03T05:50:15ZengWileyCase Reports in Urology2090-696X2090-69782016-01-01201610.1155/2016/90167289016728Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and ManagementAnand Mohapatra0Aaron M. Potretzke1Brent A. Knight2Min Han3Robert S. Figenshau4Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USAGranulosa cell tumors (GCTs) of the testis are rare sex cord-stromal tumors that are present in both juvenile and adult subtypes. While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options that have been employed in previous cases include retroperitoneal lymph node dissection (RPLND), radiation, chemotherapy, or a combination thereof. We describe the case of a 57-year-old man who presented with a painless left testicular mass and painful gynecomastia. Serum tumor markers (alpha fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase) and computed tomography of the chest and abdomen were negative. The patient underwent left radical orchiectomy. Immunohistochemical staining was consistent with a testicular GCT. He underwent a left-template laparoscopic RPLND which revealed 2/19 positive lymph nodes. Final pathological stage was IIA. He remains free of disease 32 months after surgery.http://dx.doi.org/10.1155/2016/9016728 |
| spellingShingle | Anand Mohapatra Aaron M. Potretzke Brent A. Knight Min Han Robert S. Figenshau Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management Case Reports in Urology |
| title | Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management |
| title_full | Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management |
| title_fullStr | Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management |
| title_full_unstemmed | Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management |
| title_short | Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management |
| title_sort | metastatic granulosa cell tumor of the testis clinical presentation and management |
| url | http://dx.doi.org/10.1155/2016/9016728 |
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