Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19
IntroductionSince the onset of the COVID-19 pandemic, 775 million cases have been reported globally. While many individuals recover fully, a significant proportion develop persistent symptoms. Numerous studies have investigated the long-term symptoms of COVID-19; however, the full extent and impact...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1460119/full |
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| author | Roda Alhasan Lena Rafsten Lena Rafsten Alexandra C. Larsson Alexandra C. Larsson Katharina S. Sunnerhagen Katharina S. Sunnerhagen Katharina S. Sunnerhagen Hanna C. Persson Hanna C. Persson |
| author_facet | Roda Alhasan Lena Rafsten Lena Rafsten Alexandra C. Larsson Alexandra C. Larsson Katharina S. Sunnerhagen Katharina S. Sunnerhagen Katharina S. Sunnerhagen Hanna C. Persson Hanna C. Persson |
| author_sort | Roda Alhasan |
| collection | DOAJ |
| description | IntroductionSince the onset of the COVID-19 pandemic, 775 million cases have been reported globally. While many individuals recover fully, a significant proportion develop persistent symptoms. Numerous studies have investigated the long-term symptoms of COVID-19; however, the full extent and impact of these symptoms remain inadequately understood. The aim of this study was to investigate the prevalence of self-reported persistent symptoms, focusing on respiratory symptoms and fatigue and the impact on functional status 2 years after hospitalization for COVID-19.MethodsThis study is prospective and includes participants from a longitudinal multi-center cohort that follows patients previously hospitalized due to COVID-19 (n = 211). The current study encompasses the 2-year follow-up, using post-hospitalization questionnaire surveys. Analyzed data were collected before discharge and at the 2-year follow-up. Participants were grouped by age, sex and COVID-19 severity and group comparisons where conducted. Logistic regression analysis was used to study functional impairment.ResultsTwo years after hospital discharge due to COVID-19, 125 participants completed the 2-year follow-up. The mean age of participants was 66 years (SD 12.2), and 68% were male. The majority of participants reported present respiratory symptoms (n = 83, 69%) and fatigue (n = 98, 78%) at the 2-year follow-up. Persistent respiratory symptoms and fatigue impacted functional status substantially (p = <0.001, p = 0.028, respectively). No significant differences were observed among groups depending on age, sex, or severity of COVID-19.ConclusionFor some individuals regardless of age, sex or COVID-19 severity, respiratory symptoms and fatigue may persist for up to 2 years following COVID-19. Hence, having available support from professionals knowledgeable about COVID-19 is imperative. Further research is important to unravel the mechanisms of long-term symptoms following COVID-19 and to develop effective therapeutic and rehabilitative interventions. |
| format | Article |
| id | doaj-art-445971da0fd149ef8e3f31991bd7972e |
| institution | DOAJ |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-445971da0fd149ef8e3f31991bd7972e2025-08-20T02:53:49ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011810.3389/fncel.2024.14601191460119Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19Roda Alhasan0Lena Rafsten1Lena Rafsten2Alexandra C. Larsson3Alexandra C. Larsson4Katharina S. Sunnerhagen5Katharina S. Sunnerhagen6Katharina S. Sunnerhagen7Hanna C. Persson8Hanna C. Persson9Department of Clinical Neuroscience and Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Clinical Neuroscience and Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Clinical Neuroscience and Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Clinical Neuroscience and Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Rehabilitation Medicine, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Clinical Neuroscience and Rehabilitation Medicine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, SwedenIntroductionSince the onset of the COVID-19 pandemic, 775 million cases have been reported globally. While many individuals recover fully, a significant proportion develop persistent symptoms. Numerous studies have investigated the long-term symptoms of COVID-19; however, the full extent and impact of these symptoms remain inadequately understood. The aim of this study was to investigate the prevalence of self-reported persistent symptoms, focusing on respiratory symptoms and fatigue and the impact on functional status 2 years after hospitalization for COVID-19.MethodsThis study is prospective and includes participants from a longitudinal multi-center cohort that follows patients previously hospitalized due to COVID-19 (n = 211). The current study encompasses the 2-year follow-up, using post-hospitalization questionnaire surveys. Analyzed data were collected before discharge and at the 2-year follow-up. Participants were grouped by age, sex and COVID-19 severity and group comparisons where conducted. Logistic regression analysis was used to study functional impairment.ResultsTwo years after hospital discharge due to COVID-19, 125 participants completed the 2-year follow-up. The mean age of participants was 66 years (SD 12.2), and 68% were male. The majority of participants reported present respiratory symptoms (n = 83, 69%) and fatigue (n = 98, 78%) at the 2-year follow-up. Persistent respiratory symptoms and fatigue impacted functional status substantially (p = <0.001, p = 0.028, respectively). No significant differences were observed among groups depending on age, sex, or severity of COVID-19.ConclusionFor some individuals regardless of age, sex or COVID-19 severity, respiratory symptoms and fatigue may persist for up to 2 years following COVID-19. Hence, having available support from professionals knowledgeable about COVID-19 is imperative. Further research is important to unravel the mechanisms of long-term symptoms following COVID-19 and to develop effective therapeutic and rehabilitative interventions.https://www.frontiersin.org/articles/10.3389/fncel.2024.1460119/fullCOVID-19post Covidpersistent symptomsrespiratory symptomsfatigueshortness of breath |
| spellingShingle | Roda Alhasan Lena Rafsten Lena Rafsten Alexandra C. Larsson Alexandra C. Larsson Katharina S. Sunnerhagen Katharina S. Sunnerhagen Katharina S. Sunnerhagen Hanna C. Persson Hanna C. Persson Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 Frontiers in Cellular Neuroscience COVID-19 post Covid persistent symptoms respiratory symptoms fatigue shortness of breath |
| title | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 |
| title_full | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 |
| title_fullStr | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 |
| title_full_unstemmed | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 |
| title_short | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 |
| title_sort | self reported health persistent symptoms and daily activities 2 years after hospitalization for covid 19 |
| topic | COVID-19 post Covid persistent symptoms respiratory symptoms fatigue shortness of breath |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1460119/full |
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