An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study
Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receiv...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/981274 |
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| author | İsa Yuvacı Emine Pangal Sümeyra Yuvacı Nurettin Bayram Mustafa Ataş Burhan Başkan Süleyman Demircan Ali Akal |
| author_facet | İsa Yuvacı Emine Pangal Sümeyra Yuvacı Nurettin Bayram Mustafa Ataş Burhan Başkan Süleyman Demircan Ali Akal |
| author_sort | İsa Yuvacı |
| collection | DOAJ |
| description | Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, phenylephrine 2.5%, cyclopentolate 1%, and artificial tears. At the baseline, anterior chamber parameters were assessed using a Pentacam Scheimpflug camera system, and choroidal thickness (CT) was measured using a spectral-domain OCT with Enhanced Depth Imaging (EDI) modality. All measurements were repeated again after drug administration. Results. Increases in pupil diameter, volume, and depth of anterior chamber were found to be significant (p=0.000, p=0.000, and p=0.000, resp.), while decreases in the choroidal thickness were found to be significant in subjects receiving mydriatics (p<0.05). Conclusions. The study has shown that while cyclopentolate, tropicamide, and phenylephrine cause a decrease in choroidal thickness, they also lead to an increase in the volume and depth of anterior chamber. However, no correlation was detected between anterior chamber parameters and choroidal changes after drug administration. These findings suggest that the mydriatics may affect the choroidal thickness regardless of anterior chamber parameters. This study was registered with trial registration number 2014/357. |
| format | Article |
| id | doaj-art-444c3dd211364f44a0edc453bd46036e |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-444c3dd211364f44a0edc453bd46036e2025-08-20T03:36:03ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/981274981274An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Studyİsa Yuvacı0Emine Pangal1Sümeyra Yuvacı2Nurettin Bayram3Mustafa Ataş4Burhan Başkan5Süleyman Demircan6Ali Akal7Department of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Training and Research Hospital, 38000 Kayseri, TurkeyDepartment of Ophthalmology, School of Medicine, Harran University, 63300 Sanliurfa, TurkeyAim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, phenylephrine 2.5%, cyclopentolate 1%, and artificial tears. At the baseline, anterior chamber parameters were assessed using a Pentacam Scheimpflug camera system, and choroidal thickness (CT) was measured using a spectral-domain OCT with Enhanced Depth Imaging (EDI) modality. All measurements were repeated again after drug administration. Results. Increases in pupil diameter, volume, and depth of anterior chamber were found to be significant (p=0.000, p=0.000, and p=0.000, resp.), while decreases in the choroidal thickness were found to be significant in subjects receiving mydriatics (p<0.05). Conclusions. The study has shown that while cyclopentolate, tropicamide, and phenylephrine cause a decrease in choroidal thickness, they also lead to an increase in the volume and depth of anterior chamber. However, no correlation was detected between anterior chamber parameters and choroidal changes after drug administration. These findings suggest that the mydriatics may affect the choroidal thickness regardless of anterior chamber parameters. This study was registered with trial registration number 2014/357.http://dx.doi.org/10.1155/2015/981274 |
| spellingShingle | İsa Yuvacı Emine Pangal Sümeyra Yuvacı Nurettin Bayram Mustafa Ataş Burhan Başkan Süleyman Demircan Ali Akal An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study Journal of Ophthalmology |
| title | An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study |
| title_full | An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study |
| title_fullStr | An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study |
| title_full_unstemmed | An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study |
| title_short | An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study |
| title_sort | evaluation of effects of different mydriatics on choroidal thickness by examining anterior chamber parameters the scheimpflug imaging and enhanced depth imaging oct study |
| url | http://dx.doi.org/10.1155/2015/981274 |
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