A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection

A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection

ABSTRACT Rotavirus infections remain a significant cause of morbidity and mortality in infants. The viral surface proteins VP4 and VP7 are each classified into multiple genotypes (P[1]–P[58] for VP4 and G1–G42 for VP7), which differ in their susceptibility to neutralizing antibodies; however, detail...

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Main Authors: Tomohiro Kotaki, Yuta Kanai, Kristen M. Ogden, Megumi Onishi, Kattareeya Kumthip, Pattara Khamrin, Patcharaporn Boonyos, Pornkamol Phoosangwalthong, Phakapun Singchai, Tipsuda Luechakham, Shohei Minami, Zelin Chen, Katsuhisa Hirai, Ratana Tacharoenmuang, Hiroto Mizushima, Hiroshi Ushijima, Niwat Maneekarn, Takeshi Kobayashi
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
rotavirus
VP4
VP7
genotype
reverse genetics
neutralization susceptibility
Online Access:https://journals.asm.org/doi/10.1128/mbio.00897-25
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