Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes
Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacety...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850182522883801088 |
|---|---|
| author | T. Abiko H. Sekino |
| author_facet | T. Abiko H. Sekino |
| author_sort | T. Abiko |
| collection | DOAJ |
| description | Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that
[1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. |
| format | Article |
| id | doaj-art-444bb533fe154e97a009ff93086f20ba |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-444bb533fe154e97a009ff93086f20ba2025-08-20T02:17:37ZengWileyMediators of Inflammation0962-93511466-18611997-01-0161646810.1080/09629359791956Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytesT. Abiko0H. Sekino1Kidney Research Laboratory, Kojinkai, 1– 6 Tsutsujigaoka 2-chome, Miyagino-ku, Sendai 980, JapanKidney Research Laboratory, Kojinkai, 1– 6 Tsutsujigaoka 2-chome, Miyagino-ku, Sendai 980, JapanPhe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that [1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes.http://dx.doi.org/10.1080/09629359791956 |
| spellingShingle | T. Abiko H. Sekino Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes Mediators of Inflammation |
| title | Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes |
| title_full | Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes |
| title_fullStr | Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes |
| title_full_unstemmed | Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes |
| title_short | Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes |
| title_sort | functional roles of phe12 of deacetyl thymosin β4 in the impaired blastogenic response of uraemic t lymphocytes |
| url | http://dx.doi.org/10.1080/09629359791956 |
| work_keys_str_mv | AT tabiko functionalrolesofphe12ofdeacetylthymosinb4intheimpairedblastogenicresponseofuraemictlymphocytes AT hsekino functionalrolesofphe12ofdeacetylthymosinb4intheimpairedblastogenicresponseofuraemictlymphocytes |