Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes
Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacety...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791956 |
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| Summary: | Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that
[1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. |
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| ISSN: | 0962-9351 1466-1861 |