Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

Abstract Background Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. Methods We employed...

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Bibliographic Details
Main Authors: Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Spinal cord injury (SCI)
scRNA-seq
hdWGCNA
Amantadine
Macrophage
Online Access:https://doi.org/10.1186/s12967-024-05916-y
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