A Rare Case of Human Diphallia Associated with Hypospadias
Diphallia or penile duplication is a rare congenital variant with an estimated frequency of 1 per 5 to 6 million live births. The extent of duplication varies widely and typically occurs with other malformations including urogenital, gastrointestinal, and musculoskeletal anomalies. Here we present a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2018/8293036 |
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| author | Andrey Frolov Yun Tan Mohammed Waheed-Uz-Zaman Rana John R. Martin |
| author_facet | Andrey Frolov Yun Tan Mohammed Waheed-Uz-Zaman Rana John R. Martin |
| author_sort | Andrey Frolov |
| collection | DOAJ |
| description | Diphallia or penile duplication is a rare congenital variant with an estimated frequency of 1 per 5 to 6 million live births. The extent of duplication varies widely and typically occurs with other malformations including urogenital, gastrointestinal, and musculoskeletal anomalies. Here we present a case of human diphallia that was detected during routine dissection of an 84-year-old cadaver. Upon thorough examination, this case was characterized as a complete bifid penis which was accompanied by hypospadias with no other anatomical abnormalities detected. To gain insights into the etiology of this case, we analyzed DNA procured from the body for putative genetic variants using Next Generation Sequencing (NGS) technology. Our results support clinical observations consistent with human diphallia being a polygenic syndrome and identify new genetic variants that might underlie its etiology. |
| format | Article |
| id | doaj-art-4440e32fbb7446319f2ca2526424cc05 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-4440e32fbb7446319f2ca2526424cc052025-08-20T03:36:03ZengWileyCase Reports in Urology2090-696X2090-69782018-01-01201810.1155/2018/82930368293036A Rare Case of Human Diphallia Associated with HypospadiasAndrey Frolov0Yun Tan1Mohammed Waheed-Uz-Zaman Rana2John R. Martin3Center for Anatomical Science and Education, Department of Surgery, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Schwitalla Hall M-306, St. Louis, Missouri 63104, USACenter for Anatomical Science and Education, Department of Surgery, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Schwitalla Hall M-306, St. Louis, Missouri 63104, USACenter for Anatomical Science and Education, Department of Surgery, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Schwitalla Hall M-306, St. Louis, Missouri 63104, USACenter for Anatomical Science and Education, Department of Surgery, Saint Louis University School of Medicine, 1402 S. Grand Blvd., Schwitalla Hall M-306, St. Louis, Missouri 63104, USADiphallia or penile duplication is a rare congenital variant with an estimated frequency of 1 per 5 to 6 million live births. The extent of duplication varies widely and typically occurs with other malformations including urogenital, gastrointestinal, and musculoskeletal anomalies. Here we present a case of human diphallia that was detected during routine dissection of an 84-year-old cadaver. Upon thorough examination, this case was characterized as a complete bifid penis which was accompanied by hypospadias with no other anatomical abnormalities detected. To gain insights into the etiology of this case, we analyzed DNA procured from the body for putative genetic variants using Next Generation Sequencing (NGS) technology. Our results support clinical observations consistent with human diphallia being a polygenic syndrome and identify new genetic variants that might underlie its etiology.http://dx.doi.org/10.1155/2018/8293036 |
| spellingShingle | Andrey Frolov Yun Tan Mohammed Waheed-Uz-Zaman Rana John R. Martin A Rare Case of Human Diphallia Associated with Hypospadias Case Reports in Urology |
| title | A Rare Case of Human Diphallia Associated with Hypospadias |
| title_full | A Rare Case of Human Diphallia Associated with Hypospadias |
| title_fullStr | A Rare Case of Human Diphallia Associated with Hypospadias |
| title_full_unstemmed | A Rare Case of Human Diphallia Associated with Hypospadias |
| title_short | A Rare Case of Human Diphallia Associated with Hypospadias |
| title_sort | rare case of human diphallia associated with hypospadias |
| url | http://dx.doi.org/10.1155/2018/8293036 |
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