Highly-sensitive quantification of carbamazepine and identification of its degradation and metabolism products in human liver by high performance liquid chromatography – High resolution mass spectrometry

Highly-sensitive quantification of carbamazepine and identification of its degradation and metabolism products in human liver by high performance liquid chromatography – High resolution mass spectrometry

A method for the qualitative and quantitative determination of carbamazepine in human post mortem liver tissues using high-performance liquid chromatography coupled with high-resolution mass spectrometry has been developed. Validation has been carried out and the main analytical characteristics of t...

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Bibliographic Details
Main Authors: Andrei Pirogov, Ekaterina Shirokova, Samvel Barsegyan, Nikita Gandlevskiy, Valeriya Akimova, Alessandro Barge, Aleksander Nosyrev
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Toxicology Reports
Subjects:
Carbamazepine
Liver metabolism
HPLC-HRMS
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750025000411
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