Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model

Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model

Abstract Background The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by soluble epoxide hydrolase (sEH). Inhibition of sEH has been shown to stabilize the EETs and...

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Main Authors: Shuo Wang, Chuangye Qi, Chetan Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, Sung Hee Hwang, Bruce D. Hammock, Hongjie Li, Li Gan, Hui Zheng
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Epoxyeicosatrienoic acids
Microglia
Neurodegeneration
Soluble epoxide hydrolase
Tau
Online Access:https://doi.org/10.1186/s13024-025-00844-x
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