Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women
Background: This study compares organ dysfunction, treatment strategies, and unfavorable outcome rates between pregnant and nonpregnant women admitted to the ICU with severe COVID-19, highlighting the increased susceptibility of pregnant women to respiratory infections due to physiological changes....
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2024-12-01
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| author | Małgorzata Lipińska-Gediga Waldemar Goździk Jakub Śmiechowicz Barbara Adamik |
| author_facet | Małgorzata Lipińska-Gediga Waldemar Goździk Jakub Śmiechowicz Barbara Adamik |
| author_sort | Małgorzata Lipińska-Gediga |
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| description | Background: This study compares organ dysfunction, treatment strategies, and unfavorable outcome rates between pregnant and nonpregnant women admitted to the ICU with severe COVID-19, highlighting the increased susceptibility of pregnant women to respiratory infections due to physiological changes. Methods: A retrospective, age-matched study was conducted at a referral center specializing in critical care for pregnant women. Data from 14 pregnant/postpartum and 11 nonpregnant women were analyzed at ICU admission and on days 3, 5, and 7. Results: Acute respiratory distress syndrome was diagnosed in 100% of the pregnant/postpartum group and 64% of the nonpregnant group (<i>p</i> = 0.026). Inflammatory parameters were similar between groups, except for lower ferritin levels in the pregnant/postpartum group compared to the nonpregnant (120 vs. 568 µg/L at admission and 90 vs. 616 µg/L on day 3). Creatinine, lactate, and lactate dehydrogenase levels were significantly lower in the pregnant/postpartum group. A reduction in the SOFA score was observed over time in the pregnant/postpartum group (from 7.0 to 4.0 points, <i>p</i> = 0.009), while no change was noticed in the nonpregnant group (from 3.0 to 2.5 points, <i>p</i> = 0.181). Unfavorable outcome rates were similar, with two patients from each group succumbing to the disease (<i>p</i> = 0.604). Conclusions: The findings suggest that pregnancy does not increase the risk of unfavorable outcomes among women with severe COVID-19 receiving ICU treatment. However, additional studies with larger sample sizes are needed to validate these observations. |
| format | Article |
| id | doaj-art-44359d0e777a424a9c0cf954fe5715ae |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Viruses |
| spelling | doaj-art-44359d0e777a424a9c0cf954fe5715ae2025-01-24T13:52:24ZengMDPI AGViruses1999-49152024-12-011715110.3390/v17010051Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant WomenMałgorzata Lipińska-Gediga0Waldemar Goździk1Jakub Śmiechowicz2Barbara Adamik3Clinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandClinical Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandBackground: This study compares organ dysfunction, treatment strategies, and unfavorable outcome rates between pregnant and nonpregnant women admitted to the ICU with severe COVID-19, highlighting the increased susceptibility of pregnant women to respiratory infections due to physiological changes. Methods: A retrospective, age-matched study was conducted at a referral center specializing in critical care for pregnant women. Data from 14 pregnant/postpartum and 11 nonpregnant women were analyzed at ICU admission and on days 3, 5, and 7. Results: Acute respiratory distress syndrome was diagnosed in 100% of the pregnant/postpartum group and 64% of the nonpregnant group (<i>p</i> = 0.026). Inflammatory parameters were similar between groups, except for lower ferritin levels in the pregnant/postpartum group compared to the nonpregnant (120 vs. 568 µg/L at admission and 90 vs. 616 µg/L on day 3). Creatinine, lactate, and lactate dehydrogenase levels were significantly lower in the pregnant/postpartum group. A reduction in the SOFA score was observed over time in the pregnant/postpartum group (from 7.0 to 4.0 points, <i>p</i> = 0.009), while no change was noticed in the nonpregnant group (from 3.0 to 2.5 points, <i>p</i> = 0.181). Unfavorable outcome rates were similar, with two patients from each group succumbing to the disease (<i>p</i> = 0.604). Conclusions: The findings suggest that pregnancy does not increase the risk of unfavorable outcomes among women with severe COVID-19 receiving ICU treatment. However, additional studies with larger sample sizes are needed to validate these observations.https://www.mdpi.com/1999-4915/17/1/51COVID-19acute respiratory failureacute respiratory distress syndromeorgan failurepregnancysepsis |
| spellingShingle | Małgorzata Lipińska-Gediga Waldemar Goździk Jakub Śmiechowicz Barbara Adamik Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women Viruses COVID-19 acute respiratory failure acute respiratory distress syndrome organ failure pregnancy sepsis |
| title | Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women |
| title_full | Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women |
| title_fullStr | Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women |
| title_full_unstemmed | Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women |
| title_short | Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women |
| title_sort | pregnancy and covid 19 comparing icu outcomes for pregnant and nonpregnant women |
| topic | COVID-19 acute respiratory failure acute respiratory distress syndrome organ failure pregnancy sepsis |
| url | https://www.mdpi.com/1999-4915/17/1/51 |
| work_keys_str_mv | AT małgorzatalipinskagediga pregnancyandcovid19comparingicuoutcomesforpregnantandnonpregnantwomen AT waldemargozdzik pregnancyandcovid19comparingicuoutcomesforpregnantandnonpregnantwomen AT jakubsmiechowicz pregnancyandcovid19comparingicuoutcomesforpregnantandnonpregnantwomen AT barbaraadamik pregnancyandcovid19comparingicuoutcomesforpregnantandnonpregnantwomen |