A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults
Abstract Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-09203-8 |
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| author | Chaodeng Mo Johny Bajgai Md. Habibur Rahman Soonchul Choe Sofian Abdul-Nasir Hui Ma Wenjing He Thu Thao Pham Haiyang Zhang Goh Seong Hoon Kim Bomi Cheol-Su Kim Kyu-Jae Lee Insik Shin |
| author_facet | Chaodeng Mo Johny Bajgai Md. Habibur Rahman Soonchul Choe Sofian Abdul-Nasir Hui Ma Wenjing He Thu Thao Pham Haiyang Zhang Goh Seong Hoon Kim Bomi Cheol-Su Kim Kyu-Jae Lee Insik Shin |
| author_sort | Chaodeng Mo |
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| description | Abstract Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four 5-min standardized UV exposures (UVB: 1.34 mW/cm²; UVA: 27.7 mW/cm²) on representative skin areas. Blood samples were collected before exposure and after every two sessions to assess serum vitamin D, inflammatory markers, vitamin D-related markers, and oxidative stress indicators. Serum vitamin D concentration significantly increased after four exposures (p < 0.001), while calcium, phosphorus, and parathyroid hormone (PTH) significantly decreased (p < 0.05). Reactive oxygen species (ROS) significantly increased (p < 0.001), but no significant changes were observed in nitric oxide (NO) or myeloperoxidase (MPO) levels. Similarly, inflammatory markers such as C-reactive protein (CRP), MPO, and antioxidant enzymes (glutathione peroxidase [GPx] and catalase [CAT], showed no significant alterations. Among the inflammatory cytokines assessed, interleukin (IL)-1β levels showed a slight increase without reaching significance, and the levels of other cytokines such as IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) showed no marked alterations. In addition, post-exposure skin assessment revealed no adverse effects. Our findings demonstrate that UVR exposure can enhance vitamin D synthesis in healthy adults without significant inflammatory responses or adverse effects, providing a basis for optimizing UV-based interventions to improve vitamin D status through risk management. |
| format | Article |
| id | doaj-art-4431c8534622402fa681cf795db29d3e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4431c8534622402fa681cf795db29d3e2025-08-20T03:38:15ZengNature PortfolioScientific Reports2045-23222025-07-0115111410.1038/s41598-025-09203-8A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adultsChaodeng Mo0Johny Bajgai1Md. Habibur Rahman2Soonchul Choe3Sofian Abdul-Nasir4Hui Ma5Wenjing He6Thu Thao Pham7Haiyang Zhang8Goh Seong Hoon9Kim Bomi10Cheol-Su Kim11Kyu-Jae Lee12Insik Shin13Department of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDOS AND YOUNIQUE CoDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei UniversityDepartment of Surgery, Wonju College of Medicine, Yonsei UniversityAbstract Ultraviolet radiation (UVR) is essential for vitamin D synthesis and influences various biological processes. This study examined the effects of controlled UV exposure on vitamin D synthesis and skin inflammation in healthy adults. In a randomized clinical trial, 24 volunteers received four 5-min standardized UV exposures (UVB: 1.34 mW/cm²; UVA: 27.7 mW/cm²) on representative skin areas. Blood samples were collected before exposure and after every two sessions to assess serum vitamin D, inflammatory markers, vitamin D-related markers, and oxidative stress indicators. Serum vitamin D concentration significantly increased after four exposures (p < 0.001), while calcium, phosphorus, and parathyroid hormone (PTH) significantly decreased (p < 0.05). Reactive oxygen species (ROS) significantly increased (p < 0.001), but no significant changes were observed in nitric oxide (NO) or myeloperoxidase (MPO) levels. Similarly, inflammatory markers such as C-reactive protein (CRP), MPO, and antioxidant enzymes (glutathione peroxidase [GPx] and catalase [CAT], showed no significant alterations. Among the inflammatory cytokines assessed, interleukin (IL)-1β levels showed a slight increase without reaching significance, and the levels of other cytokines such as IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) showed no marked alterations. In addition, post-exposure skin assessment revealed no adverse effects. Our findings demonstrate that UVR exposure can enhance vitamin D synthesis in healthy adults without significant inflammatory responses or adverse effects, providing a basis for optimizing UV-based interventions to improve vitamin D status through risk management.https://doi.org/10.1038/s41598-025-09203-8Ultraviolet exposureVitamin D synthesisInflammationOxidative stressClinical trial |
| spellingShingle | Chaodeng Mo Johny Bajgai Md. Habibur Rahman Soonchul Choe Sofian Abdul-Nasir Hui Ma Wenjing He Thu Thao Pham Haiyang Zhang Goh Seong Hoon Kim Bomi Cheol-Su Kim Kyu-Jae Lee Insik Shin A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults Scientific Reports Ultraviolet exposure Vitamin D synthesis Inflammation Oxidative stress Clinical trial |
| title | A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults |
| title_full | A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults |
| title_fullStr | A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults |
| title_full_unstemmed | A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults |
| title_short | A pilot clinical trial to explore the effects of UV exposure on vitamin D synthesis and inflammatory responses in vitamin D-Deficient adults |
| title_sort | pilot clinical trial to explore the effects of uv exposure on vitamin d synthesis and inflammatory responses in vitamin d deficient adults |
| topic | Ultraviolet exposure Vitamin D synthesis Inflammation Oxidative stress Clinical trial |
| url | https://doi.org/10.1038/s41598-025-09203-8 |
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