Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct

Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct

The SARS-CoV-2 spike protein is synthesized in the endoplasmic reticulum of host cells, from where it undergoes export to the Golgi and the plasma membrane or retrieval from the Golgi to the endoplasmic reticulum. Elucidating the fundamental principles of this bidirectional secretion are pivotal to...

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Bibliographic Details
Main Authors: Suruchi Singh, Yi Liu, Meghan Burke, Vamseedhar Rayaprolu, Stephen E. Stein, S. Saif Hasan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Structural Biology: X
Subjects:
Spike
Single particle cryoEM
AlphaFold
Purification
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152425000042
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