An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics
The mechanism of atherosclerosis lesions was investigated based on a fluid–structure interaction method according to the geometric reconstruction of human arteries by medical imaging. Numerical simulation, mechanical analysis, and dynamic simulation were used to establish a model of the mechanical c...
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MDPI AG
2025-04-01
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| author | Lei Guo Ye Lu Shusheng Zhang |
| author_facet | Lei Guo Ye Lu Shusheng Zhang |
| author_sort | Lei Guo |
| collection | DOAJ |
| description | The mechanism of atherosclerosis lesions was investigated based on a fluid–structure interaction method according to the geometric reconstruction of human arteries by medical imaging. Numerical simulation, mechanical analysis, and dynamic simulation were used to establish a model of the mechanical characteristics of arterial blood transport, analyze the fluid properties of arterial blood flow under the influence of vascular lesion process, and study the mechanism of arterial lesion formation and development. The results indicated that the clinically important areas of secondary flow were generated at stenosis and bifurcation sites, which were prone to lesions during a cardiac cycle. The low flow rate and shear stress levels of blood in this region led to the adhesion and precipitation of lesion-inducing factors on the intimal tissue, creating a hydrodynamic environment suitable for lesion development. According to the research reported here in, early clinical detection and follow-up of atherosclerosis can be performed by collecting data on wall shear stress and blood flow pressure difference. |
| format | Article |
| id | doaj-art-4430574582d64fed8bd6920f98779ce4 |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-4430574582d64fed8bd6920f98779ce42025-08-20T02:09:13ZengMDPI AGApplied Sciences2076-34172025-04-01157405510.3390/app15074055An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on HemodynamicsLei Guo0Ye Lu1Shusheng Zhang2School of Physics, Electronics and Intelligent Manufacturing, Huaihua University, Huaihua 418000, ChinaInstitute of Thermal Science & Technology, Shandong University, Jinan 250000, ChinaInstitute of Thermal Science & Technology, Shandong University, Jinan 250000, ChinaThe mechanism of atherosclerosis lesions was investigated based on a fluid–structure interaction method according to the geometric reconstruction of human arteries by medical imaging. Numerical simulation, mechanical analysis, and dynamic simulation were used to establish a model of the mechanical characteristics of arterial blood transport, analyze the fluid properties of arterial blood flow under the influence of vascular lesion process, and study the mechanism of arterial lesion formation and development. The results indicated that the clinically important areas of secondary flow were generated at stenosis and bifurcation sites, which were prone to lesions during a cardiac cycle. The low flow rate and shear stress levels of blood in this region led to the adhesion and precipitation of lesion-inducing factors on the intimal tissue, creating a hydrodynamic environment suitable for lesion development. According to the research reported here in, early clinical detection and follow-up of atherosclerosis can be performed by collecting data on wall shear stress and blood flow pressure difference.https://www.mdpi.com/2076-3417/15/7/4055atherosclerosishemodynamicsfluid–structure interactionsnumerical simulationwall shear stressblood flow pressure |
| spellingShingle | Lei Guo Ye Lu Shusheng Zhang An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics Applied Sciences atherosclerosis hemodynamics fluid–structure interactions numerical simulation wall shear stress blood flow pressure |
| title | An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics |
| title_full | An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics |
| title_fullStr | An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics |
| title_full_unstemmed | An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics |
| title_short | An Assisted Numerical Simulation Diagnosis Method for Atherosclerosis Based on Hemodynamics |
| title_sort | assisted numerical simulation diagnosis method for atherosclerosis based on hemodynamics |
| topic | atherosclerosis hemodynamics fluid–structure interactions numerical simulation wall shear stress blood flow pressure |
| url | https://www.mdpi.com/2076-3417/15/7/4055 |
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