Bioactive oligopeptides and the application in skin regeneration and rejuvenation

Oligopeptides, composed of 2–10 amino acid residues, are protein fragments with unique structural characteristics, including small molecular size, high biocompatibility, and modifiable functional groups. These features endow oligopeptides with excellent permeability, safety, and versatile biological...

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Bibliographic Details
Main Authors: Qiulin He, Youguo Liao, Yaru Wu, Huahui Zhang, Xiaohui Long, Yuxiang Zhang
Format: Article
Language:English
Published: SAGE Publishing 2025-04-01
Series:Journal of Applied Biomaterials & Functional Materials
Online Access:https://doi.org/10.1177/22808000251330974
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Summary:Oligopeptides, composed of 2–10 amino acid residues, are protein fragments with unique structural characteristics, including small molecular size, high biocompatibility, and modifiable functional groups. These features endow oligopeptides with excellent permeability, safety, and versatile biological activities, making them widely applicable in disease treatment, drug delivery, and skincare. In particular, oligopeptides have emerged as advanced ingredients in skincare, offering anti-aging, anti-wrinkle, and whitening effects by regulating key biological processes such as collagen synthesis, antioxidant defense, and melanin production. This review comprehensively discusses the structural properties, functional mechanisms, and diverse applications of oligopeptides and their derivatives, highlighting their potential in skin regeneration, rejuvenation, and anti-aging medicine. By providing insights into the latest advancements, this review aims to serve as a valuable reference for future research and development in oligopeptide-based therapeutics and skincare innovations.
ISSN:2280-8000