The Role of In Vivo Confocal Microscopy in Ocular Allergies
In vivo confocal microscopy (IVCM) is a non-invasive imaging technique used to visualize the layers of the cornea and conjunctiva in real time. In patients with atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC), this technology can be useful in diagnosing and monitoring the dis...
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Galenos Yayinevi
2024-12-01
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| Series: | Türk Oftalmoloji Dergisi |
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| Online Access: | https://www.oftalmoloji.org/articles/the-role-of-in-vivo-confocal-microscopy-in-ocular-allergies/doi/tjo.galenos.2024.49769 |
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| author | Cem Şimşek Takashi Kojima Murat Doğru |
| author_facet | Cem Şimşek Takashi Kojima Murat Doğru |
| author_sort | Cem Şimşek |
| collection | DOAJ |
| description | In vivo confocal microscopy (IVCM) is a non-invasive imaging technique used to visualize the layers of the cornea and conjunctiva in real time. In patients with atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC), this technology can be useful in diagnosing and monitoring the disease, as well as evaluating the efficacy of treatments. IVCM can reveal subclinical abnormalities in the corneal and conjunctival epithelium such as inflammatory cell infiltrates and tissue damage, which can provide insight into the pathogenesis of AKC. In AKC, IVCM reveals changes around the conjunctival papillae, inflammatory cells around punctate defects in the corneal epithelium, changes in subbasal nerve morphology, and deteriorations in the goblet cells in the meibomian gland are observed. In VKC, alterations can be observed in the diameter, brightness and nucleus/cytoplasm ratio of the superficial epithelial cells in the cornea. The use of IVCM in AKC and VKC can therefore aid in the early detection and management of the disease, as well as contribute to a better understanding of its underlying mechanisms. |
| format | Article |
| id | doaj-art-4429fabfb71143a190c92da47e6b8286 |
| institution | Kabale University |
| issn | 1300-0659 2147-2661 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj-art-4429fabfb71143a190c92da47e6b82862025-01-07T08:21:22ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612024-12-0154634435310.4274/tjo.galenos.2024.49769The Role of In Vivo Confocal Microscopy in Ocular AllergiesCem Şimşek0https://orcid.org/0000-0001-8003-745XTakashi Kojima1https://orcid.org/0000-0002-5016-0155Murat Doğru2https://orcid.org/0000-0003-1487-2435Muğla Sıtkı Koçman University Faculty of Medicine, Department of Ophthalmology, Muğla, TürkiyeKeio University Faculty of Medicine, Department of Ophthalmology, Tokyo, JapanKeio University Faculty of Medicine, Department of Ophthalmology, Tokyo, JapanIn vivo confocal microscopy (IVCM) is a non-invasive imaging technique used to visualize the layers of the cornea and conjunctiva in real time. In patients with atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC), this technology can be useful in diagnosing and monitoring the disease, as well as evaluating the efficacy of treatments. IVCM can reveal subclinical abnormalities in the corneal and conjunctival epithelium such as inflammatory cell infiltrates and tissue damage, which can provide insight into the pathogenesis of AKC. In AKC, IVCM reveals changes around the conjunctival papillae, inflammatory cells around punctate defects in the corneal epithelium, changes in subbasal nerve morphology, and deteriorations in the goblet cells in the meibomian gland are observed. In VKC, alterations can be observed in the diameter, brightness and nucleus/cytoplasm ratio of the superficial epithelial cells in the cornea. The use of IVCM in AKC and VKC can therefore aid in the early detection and management of the disease, as well as contribute to a better understanding of its underlying mechanisms.https://www.oftalmoloji.org/articles/the-role-of-in-vivo-confocal-microscopy-in-ocular-allergies/doi/tjo.galenos.2024.49769atopic keratoconjunctivitisvernal keratoconjunctivitisin vivo confocal microscopycorneaconjunctivameibomian glands |
| spellingShingle | Cem Şimşek Takashi Kojima Murat Doğru The Role of In Vivo Confocal Microscopy in Ocular Allergies Türk Oftalmoloji Dergisi atopic keratoconjunctivitis vernal keratoconjunctivitis in vivo confocal microscopy cornea conjunctiva meibomian glands |
| title | The Role of In Vivo Confocal Microscopy in Ocular Allergies |
| title_full | The Role of In Vivo Confocal Microscopy in Ocular Allergies |
| title_fullStr | The Role of In Vivo Confocal Microscopy in Ocular Allergies |
| title_full_unstemmed | The Role of In Vivo Confocal Microscopy in Ocular Allergies |
| title_short | The Role of In Vivo Confocal Microscopy in Ocular Allergies |
| title_sort | role of in vivo confocal microscopy in ocular allergies |
| topic | atopic keratoconjunctivitis vernal keratoconjunctivitis in vivo confocal microscopy cornea conjunctiva meibomian glands |
| url | https://www.oftalmoloji.org/articles/the-role-of-in-vivo-confocal-microscopy-in-ocular-allergies/doi/tjo.galenos.2024.49769 |
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