Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity
A novel ampholytic cellulose derivative, cellulose-L-methionine, has been synthesized by means of an esterification reaction of microcrystalline cellulose with tosyl chloride (p-TsCl) in DMAc/LiCl (8%) at 8°C that was followed by nucleophilic displacement (SN) of the tosyl group by the L-methionine...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2021/6613684 |
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| author | Lahcen El Hamdaoui Ahmed Talbaoui Mohammed El Moussaouiti |
| author_facet | Lahcen El Hamdaoui Ahmed Talbaoui Mohammed El Moussaouiti |
| author_sort | Lahcen El Hamdaoui |
| collection | DOAJ |
| description | A novel ampholytic cellulose derivative, cellulose-L-methionine, has been synthesized by means of an esterification reaction of microcrystalline cellulose with tosyl chloride (p-TsCl) in DMAc/LiCl (8%) at 8°C that was followed by nucleophilic displacement (SN) of the tosyl group by the L-methionine amino acid. The resulting structure of cellulose-L-methionine has been characterized by elemental analysis (CHNSO), Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR), and scanning electron microscopy (SEM). The antibacterial activity of the synthesized product was screened against Gram-positive and Gram-negative microbial strains such as Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, by the agar well diffusion method, and compared with commercial antibiotics such as ampicillin and chloramphenicol. It was found that antibacterial experiment revealed excellent antibacterial activity of the cellulose-methionine with respect to a minimal inhibitory concentration (MIC) reference. |
| format | Article |
| id | doaj-art-44250bacd31a4b248d55dd34a59e86e5 |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-44250bacd31a4b248d55dd34a59e86e52025-08-20T02:05:51ZengWileyInternational Journal of Polymer Science1687-94221687-94302021-01-01202110.1155/2021/66136846613684Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial ActivityLahcen El Hamdaoui0Ahmed Talbaoui1Mohammed El Moussaouiti2Laboratory of Materials, Nanotechnology and Environment, Center of Materials Sciences, Faculty of Sciences, Mohammed V University in Rabat, Rabat, MoroccoLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University in Rabat, Rabat, MoroccoLaboratory of Materials, Nanotechnology and Environment, Center of Materials Sciences, Faculty of Sciences, Mohammed V University in Rabat, Rabat, MoroccoA novel ampholytic cellulose derivative, cellulose-L-methionine, has been synthesized by means of an esterification reaction of microcrystalline cellulose with tosyl chloride (p-TsCl) in DMAc/LiCl (8%) at 8°C that was followed by nucleophilic displacement (SN) of the tosyl group by the L-methionine amino acid. The resulting structure of cellulose-L-methionine has been characterized by elemental analysis (CHNSO), Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR), and scanning electron microscopy (SEM). The antibacterial activity of the synthesized product was screened against Gram-positive and Gram-negative microbial strains such as Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, by the agar well diffusion method, and compared with commercial antibiotics such as ampicillin and chloramphenicol. It was found that antibacterial experiment revealed excellent antibacterial activity of the cellulose-methionine with respect to a minimal inhibitory concentration (MIC) reference.http://dx.doi.org/10.1155/2021/6613684 |
| spellingShingle | Lahcen El Hamdaoui Ahmed Talbaoui Mohammed El Moussaouiti Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity International Journal of Polymer Science |
| title | Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity |
| title_full | Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity |
| title_fullStr | Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity |
| title_full_unstemmed | Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity |
| title_short | Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity |
| title_sort | nucleophilic displacement reaction on tosyl cellulose by l methionine to the synthesis of novel water soluble cellulose derivative and its antibacterial activity |
| url | http://dx.doi.org/10.1155/2021/6613684 |
| work_keys_str_mv | AT lahcenelhamdaoui nucleophilicdisplacementreactionontosylcellulosebylmethioninetothesynthesisofnovelwatersolublecellulosederivativeanditsantibacterialactivity AT ahmedtalbaoui nucleophilicdisplacementreactionontosylcellulosebylmethioninetothesynthesisofnovelwatersolublecellulosederivativeanditsantibacterialactivity AT mohammedelmoussaouiti nucleophilicdisplacementreactionontosylcellulosebylmethioninetothesynthesisofnovelwatersolublecellulosederivativeanditsantibacterialactivity |