Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment
Regulatory immune cells regulate immune responses through various mechanisms, affecting the occurrence, development, and therapeutic effects of tumors. In this article, we reviewed the important roles of regulatory immune cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481850/full |
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| author | Peng Song Peng Song Fei Song Fei Song Tingting Shao Tingting Shao Pengjuan Wang Pengjuan Wang Rongkun Li Rongkun Li Zhe-Sheng Chen Zhaofang Zhang Zhaofang Zhang Guozhong Xue Guozhong Xue |
| author_facet | Peng Song Peng Song Fei Song Fei Song Tingting Shao Tingting Shao Pengjuan Wang Pengjuan Wang Rongkun Li Rongkun Li Zhe-Sheng Chen Zhaofang Zhang Zhaofang Zhang Guozhong Xue Guozhong Xue |
| author_sort | Peng Song |
| collection | DOAJ |
| description | Regulatory immune cells regulate immune responses through various mechanisms, affecting the occurrence, development, and therapeutic effects of tumors. In this article, we reviewed the important roles of regulatory immune cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid-derived suppressor cells (MDSCs), regulatory dendritic cells (DCregs), and tumor-associated macrophages (TAMs), in the tumor microenvironment (TME). The immunomodulatory effects of natural products, such as polysaccharides, polyphenols, glycosides, alkaloids, terpenoids, quinones, and other compounds, which affect the functions of regulatory immune cells through molecular signaling pathways, thereby enhancing the potential of the antitumor immune response, are discussed. These findings provide new ideas and possibilities for the application of natural products in tumor treatment, which can help enhance the effectiveness of tumor treatment and improve patient prognosis. |
| format | Article |
| id | doaj-art-442285774b2d4adbbe2956059c71af7b |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-442285774b2d4adbbe2956059c71af7b2024-11-13T04:39:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.14818501481850Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironmentPeng Song0Peng Song1Fei Song2Fei Song3Tingting Shao4Tingting Shao5Pengjuan Wang6Pengjuan Wang7Rongkun Li8Rongkun Li9Zhe-Sheng Chen10Zhaofang Zhang11Zhaofang Zhang12Guozhong Xue13Guozhong Xue14Gansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaCollege of Pharmacy and Health Sciences, St. John’s University, Queens, NY, United StatesGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaGansu University of Chinese Medicine, Lanzhou, ChinaAffiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, ChinaRegulatory immune cells regulate immune responses through various mechanisms, affecting the occurrence, development, and therapeutic effects of tumors. In this article, we reviewed the important roles of regulatory immune cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid-derived suppressor cells (MDSCs), regulatory dendritic cells (DCregs), and tumor-associated macrophages (TAMs), in the tumor microenvironment (TME). The immunomodulatory effects of natural products, such as polysaccharides, polyphenols, glycosides, alkaloids, terpenoids, quinones, and other compounds, which affect the functions of regulatory immune cells through molecular signaling pathways, thereby enhancing the potential of the antitumor immune response, are discussed. These findings provide new ideas and possibilities for the application of natural products in tumor treatment, which can help enhance the effectiveness of tumor treatment and improve patient prognosis.https://www.frontiersin.org/articles/10.3389/fphar.2024.1481850/fullregulatory immune cellsnatural productspolysaccharidespolyphenolstumor therapy |
| spellingShingle | Peng Song Peng Song Fei Song Fei Song Tingting Shao Tingting Shao Pengjuan Wang Pengjuan Wang Rongkun Li Rongkun Li Zhe-Sheng Chen Zhaofang Zhang Zhaofang Zhang Guozhong Xue Guozhong Xue Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment Frontiers in Pharmacology regulatory immune cells natural products polysaccharides polyphenols tumor therapy |
| title | Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| title_full | Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| title_fullStr | Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| title_full_unstemmed | Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| title_short | Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| title_sort | natural products promising therapeutics for targeting regulatory immune cells in the tumor microenvironment |
| topic | regulatory immune cells natural products polysaccharides polyphenols tumor therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481850/full |
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