Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review
Atopic dermatitis (AD) is a complex systemic disease characterized by high heterogeneity both at clinical and pathophysiology levels. While advances in drug development toward a more targeted approach are made, treatment and management of AD patients are still happening according to the one-size-fit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1574697/full |
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| author | Andrea Chiricozzi Andrea Chiricozzi Anna Levi Chiara Palladino Giampiero Girolomoni |
| author_facet | Andrea Chiricozzi Andrea Chiricozzi Anna Levi Chiara Palladino Giampiero Girolomoni |
| author_sort | Andrea Chiricozzi |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a complex systemic disease characterized by high heterogeneity both at clinical and pathophysiology levels. While advances in drug development toward a more targeted approach are made, treatment and management of AD patients are still happening according to the one-size-fits-all approach. To enhance precision medicine in AD and improve care, identifying predicting factors of response to therapy driving tailored treatments will be of utmost importance. Here, we discuss the available evidence regarding predictive biomarkers, as well as their possible and still debated impact in clinical practice. |
| format | Article |
| id | doaj-art-441f5c34bc58491bb31df2478aedb0f9 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-441f5c34bc58491bb31df2478aedb0f92025-08-20T02:11:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15746971574697Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative reviewAndrea Chiricozzi0Andrea Chiricozzi1Anna Levi2Chiara Palladino3Giampiero Girolomoni4Unit of Dermatology, Department of Medical and Surgical Sciences, IRCCS A. Gemelli University Polyclinic Foundation, Rome, ItalySection of Dermatology, Department of Medicine and Translational Surgery, Sacred Heart Catholic University, Rome, ItalyAbbVie Srl, Rome, ItalyAbbVie Srl, Rome, ItalyDepartment of Medicine, Section of Dermatology, University of Verona, Verona, ItalyAtopic dermatitis (AD) is a complex systemic disease characterized by high heterogeneity both at clinical and pathophysiology levels. While advances in drug development toward a more targeted approach are made, treatment and management of AD patients are still happening according to the one-size-fits-all approach. To enhance precision medicine in AD and improve care, identifying predicting factors of response to therapy driving tailored treatments will be of utmost importance. Here, we discuss the available evidence regarding predictive biomarkers, as well as their possible and still debated impact in clinical practice.https://www.frontiersin.org/articles/10.3389/fmed.2025.1574697/fullatopic dermatitistargeted therapiespredictive biomarkersprecision medicinepersonalized approach |
| spellingShingle | Andrea Chiricozzi Andrea Chiricozzi Anna Levi Chiara Palladino Giampiero Girolomoni Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review Frontiers in Medicine atopic dermatitis targeted therapies predictive biomarkers precision medicine personalized approach |
| title | Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review |
| title_full | Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review |
| title_fullStr | Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review |
| title_full_unstemmed | Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review |
| title_short | Enabling precision medicine with biomarkers of response to treatment in atopic dermatitis: where are we now? A narrative review |
| title_sort | enabling precision medicine with biomarkers of response to treatment in atopic dermatitis where are we now a narrative review |
| topic | atopic dermatitis targeted therapies predictive biomarkers precision medicine personalized approach |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1574697/full |
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