Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database
BackgroundPrevious studies have shown that inflammation is crucial in gallstone formation. The Advanced Lung Cancer Inflammation Index (ALI) is a comprehensive measure that reflects inflammation and nutritional condition. However, there are no studies examining the relationship between ALI and galls...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1506477/full |
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| author | Bailiang Liu Luyuan Jin Boyuan Nan Zhongyi Sun Fengyang Chen Yinghui Zhou Qila Sa Qila Sa Yingnan Feng Yingnan Feng Ao Men Ao Men Wenxin Wang Wenxin Wang Xiaodong Feng Wei Zhang |
| author_facet | Bailiang Liu Luyuan Jin Boyuan Nan Zhongyi Sun Fengyang Chen Yinghui Zhou Qila Sa Qila Sa Yingnan Feng Yingnan Feng Ao Men Ao Men Wenxin Wang Wenxin Wang Xiaodong Feng Wei Zhang |
| author_sort | Bailiang Liu |
| collection | DOAJ |
| description | BackgroundPrevious studies have shown that inflammation is crucial in gallstone formation. The Advanced Lung Cancer Inflammation Index (ALI) is a comprehensive measure that reflects inflammation and nutritional condition. However, there are no studies examining the relationship between ALI and gallstones. This study aimed to analyze this association in US adults.MethodsThis study used a cross-sectional research design with in-depth analyses using data from the National Health and Nutrition Examination Survey (NHANES). The association between gallstones and ALI was systematically assessed by logistic regression analysis, subgroup analysis, basic participant characteristics, and smooth curve fits.Results5,646 people participated in the study. ALI was converted into Quartile 1 (−1.47–1.00), Quartile 2 (1.00–1.34), Quartile 3 (1.34–1.69), and Quartile 4 (1.69–4.38). In the fully adjusted model, gallstone prevalence increased by 45% in participants in the highest quartile compared to those in the lowest quartile (OR = 1.45; 95% CI: 1.12–1.87; p = 0.005), and ALI was positively correlated with gallstones (OR = 1.22; 95% CI: 1.03–1.45; p = 0.0232). Smooth curve fits provided evidence in favor of this finding. Significant gender differences were found in the relationship between gallstones and ALI by subgroup analysis (OR = 1.43; 95% CI: 1.16–1.76; p for interaction = 0.0204).ConclusionThe study concluded that ALI and gallstones had a positive correlation, with ALI having a higher effect on women’s gallstone prevalence. |
| format | Article |
| id | doaj-art-441f2bdb24a04c459c84918591c7cd27 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-441f2bdb24a04c459c84918591c7cd272025-08-20T02:34:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.15064771506477Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES databaseBailiang Liu0Luyuan Jin1Boyuan Nan2Zhongyi Sun3Fengyang Chen4Yinghui Zhou5Qila Sa6Qila Sa7Yingnan Feng8Yingnan Feng9Ao Men10Ao Men11Wenxin Wang12Wenxin Wang13Xiaodong Feng14Wei Zhang15Department of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Dalian Medical University, Dalian, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Dalian Medical University, Dalian, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Dalian Medical University, Dalian, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Dalian Medical University, Dalian, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, ChinaBackgroundPrevious studies have shown that inflammation is crucial in gallstone formation. The Advanced Lung Cancer Inflammation Index (ALI) is a comprehensive measure that reflects inflammation and nutritional condition. However, there are no studies examining the relationship between ALI and gallstones. This study aimed to analyze this association in US adults.MethodsThis study used a cross-sectional research design with in-depth analyses using data from the National Health and Nutrition Examination Survey (NHANES). The association between gallstones and ALI was systematically assessed by logistic regression analysis, subgroup analysis, basic participant characteristics, and smooth curve fits.Results5,646 people participated in the study. ALI was converted into Quartile 1 (−1.47–1.00), Quartile 2 (1.00–1.34), Quartile 3 (1.34–1.69), and Quartile 4 (1.69–4.38). In the fully adjusted model, gallstone prevalence increased by 45% in participants in the highest quartile compared to those in the lowest quartile (OR = 1.45; 95% CI: 1.12–1.87; p = 0.005), and ALI was positively correlated with gallstones (OR = 1.22; 95% CI: 1.03–1.45; p = 0.0232). Smooth curve fits provided evidence in favor of this finding. Significant gender differences were found in the relationship between gallstones and ALI by subgroup analysis (OR = 1.43; 95% CI: 1.16–1.76; p for interaction = 0.0204).ConclusionThe study concluded that ALI and gallstones had a positive correlation, with ALI having a higher effect on women’s gallstone prevalence.https://www.frontiersin.org/articles/10.3389/fnut.2024.1506477/fulladvanced lung cancer inflammation indexgallstonesNHANESinflammationnutritioncross-sectional study |
| spellingShingle | Bailiang Liu Luyuan Jin Boyuan Nan Zhongyi Sun Fengyang Chen Yinghui Zhou Qila Sa Qila Sa Yingnan Feng Yingnan Feng Ao Men Ao Men Wenxin Wang Wenxin Wang Xiaodong Feng Wei Zhang Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database Frontiers in Nutrition advanced lung cancer inflammation index gallstones NHANES inflammation nutrition cross-sectional study |
| title | Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database |
| title_full | Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database |
| title_fullStr | Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database |
| title_full_unstemmed | Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database |
| title_short | Positive association between advanced lung cancer inflammation index and gallstones, with greater impact on women: a cross-sectional study of the NHANES database |
| title_sort | positive association between advanced lung cancer inflammation index and gallstones with greater impact on women a cross sectional study of the nhanes database |
| topic | advanced lung cancer inflammation index gallstones NHANES inflammation nutrition cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1506477/full |
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